Evidence map›Paper›PMID 21138324›Full record

ReviewJournal of natural products2011

Modern natural products drug discovery and its relevance to biodiversity conservation.

David G I Kingston

Abstract readReview
In one paragraph

Review in Journal of natural products, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. BioprospectingFrontiers in fungal biology · 2021
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Plants (Basel, Switzerland) · 2024
    Article
  14. Discovery of anti-infective compounds againstFrontiers in microbiology · 2024
    Article
  15. Latin American Plants against Microorganisms.Plants (Basel, Switzerland) · 2023
    Review
  16. Review
  17. Article
  18. Motifs in Natural Products as Useful Scaffolds to Obtain Novel Benzo[International journal of molecular sciences · 2023
    Article
  19. Article
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David G I KingstonDepartment of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States. dkingston@vt.edu

Funding

BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAMEU01TW000313 · FIC · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KINGSTON, DAVID GEORGE IAN · 1993 to 2013
$9.5M
FIC/SCHOLARS-IN-RESIDENCE PROGRAMF15TW000313 · FIC · U.S. NATIONAL INSTITUTES OF HEALTH · PI JENSEN, ELWOOD V · 1988 to 1989
–
FIC NIH HHS U01 TW000313
6 · The paper itself

Abstract

Natural products continue to provide a diverse and unique source of bioactive lead compounds for drug discovery, but maintaining their continued eminence as source compounds is challenging in the face of the changing face of the pharmaceutical industry and the changing nature of biodiversity prospecting brought about by the Convention on Biological Diversity. This review provides an overview of some of these challenges and suggests ways in which they can be addressed so that natural products research can remain a viable and productive route to drug discovery. Results from International Cooperative Biodiversity Groups (ICBGs) working in Madagascar, Panama, and Suriname are used as examples of what can be achieved when biodiversity conservation is linked to drug discovery.

Indexed as

BiodiversityBiological ProductsDrug DiscoveryDrug IndustryMadagascarMolecular StructurePanamaSurinameBiological Products

Identifiers

PMID21138324
PMCPMC3061248

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.