ArticleJournal of the American Chemical Society2010
QM/MM studies of monozinc β-lactamase CphA suggest that the crystal structure of an enzyme-intermediate complex represents a minor pathway.
Article in Journal of the American Chemical Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 62 citations in OpenAlex.
- How Do DICER1 Syndrome Mutations Disrupt Catalysis? Unveiling Dicer Metal Binding Architecture and Mechanism of Action Using MD Simulations and QM/MM Calculations.Journal of computational chemistry · 2026Article
- The biogenesis of β-lactamase enzymes.Microbiology (Reading, England) · 2022Review
- A multiscale approach to predict the binding mode of metallo beta-lactamase inhibitors.Proteins · 2022Article
- Metallo-ß-lactamases: a review.Molecular biology reports · 2020Review
- Metallo-β-Lactamase Inhibitors Inspired on Snapshots from the Catalytic Mechanism.Biomolecules · 2020Review
- QM/MM investigation of substrate binding of subclass B3 metallo-β-lactamase SMB-1 from Serratia marcescents: insights into catalytic mechanism.Journal of molecular modeling · 2020Article
- Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.Journal of medicinal chemistry · 2019Article
- A fundamental catalytic difference between zinc and manganese dependent enzymes revealed in a bacterial isatin hydrolase.Scientific reports · 2018Article
- Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations.Scientific reports · 2016Article
- B1-Metallo-β-Lactamases: Where Do We Stand?Current drug targets · 2016Review
- Mechanistic insights into cobalt(ii/iii)-catalyzed C-H oxidation: a combined theoretical and experimental study.Chemical science · 2015Article
- QM/MM molecular dynamics studies of metal binding proteins.Biomolecules · 2014Review
- A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-β-lactamase-1.Journal of computer-aided molecular design · 2013Article
- Metallo-β-lactamase structure and function.Annals of the New York Academy of Sciences · 2013Review
- Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the hydrolysis reaction.PloS one · 2013Article
- On the active site of mononuclear B1 metallo β-lactamases: a computational study.Journal of computer-aided molecular design · 2012Article
- Catalytic mechanism of aromatic prenylation by NphB.Biochemistry · 2012Article
- Insights into the mechanistic dichotomy of the protein farnesyltransferase peptide substrates CVIM and CVLS.Journal of the American Chemical Society · 2012Article
- Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions.PloS one · 2012Article
- Carbapenems: past, present, and future.Antimicrobial agents and chemotherapy · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
QM/MM studies of the hydrolysis of a β-lactam antibiotic molecule (biapenem) catalyzed by a monozinc β-lactamase (CphA) have revealed the complete reaction mechanism and shown that an experimentally determined enzyme-intermediate complex is a stable intermediate or product in a minor pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.