ArticleVirchows Archiv. A, Pathological anatomy and histopathology1990
Diagnosis of primary cerebral lymphoma with particular reference to CT-guided stereotactic biopsy.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Analysis of False-negative Findings of the Incomparable Accuracy and Swiftness of Flow Cytometric Diagnosis of Primary Central Nervous System Lymphoma.Neurologia medico-chirurgica · 2023Article
- Clinical application of the RONNA G4 system - preliminary validation of 23 robotic frameless brain biopsies.Croatian medical journal · 2021Article
- [Diagnosis of an initial infratentorial central nervous system B-cell lymphoma during prolonged cortisone medication].Der Nervenarzt · 2004Article
- A new xenograft model of primary central nervous system lymphoma.Journal of neuro-oncology · 1999Article
- Primary T-cell lymphoma of the brain in acquired immunodeficiency syndrome: case report.Journal of neuro-oncology · 1997Article
- Occult systemic non-Hodgkin's lymphoma (NHL) in patients initially diagnosed as primary central nervous system lymphoma (PCNSL): how much staging is enough?Journal of neuro-oncology · 1995Article
- Primary central nervous system lymphoma.Journal of neuro-oncology · 1994Review
- A case of primary central nervous system lymphoma (PCNSL) of putative T-cell lineage.Journal of neuro-oncology · 1994Article
- CT-guided and computer assisted stereotactic biopsy. Technique, results, indications.Acta neurochirurgica · 1993Article
- Primary cerebral malignant non-Hodgkin's lymphomas: a retrospective clinical study.Journal of neurology · 1992Review
- Cerebellar T-cell lymphoma: an unusual primary intracranial neoplasm.Neuroradiology · 1992Article
- Primary central nervous system lymphomas--an update.Journal of cancer research and clinical oncology · 1992Review
- Accuracy of stereotactic brain tumor biopsy: comparison of the histologic findings in biopsy cylinders and resected tumor tissue.Neurosurgical review · 1991Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In establishing the histological diagnosis of primary cerebral lymphoma, stereotactic brain tumour biopsy is the method of choice as the mainstay of therapy is radiation and chemotherapy. This study describes the histopathology and diagnostic immunohistochemistry of 54 primary brain lymphomas in a mainly non-AIDS population. The stereotactic biopsies were performed using the Leksell CT stereotactic frame and a spiral needle which procured about 10-mm-long tissue cylinders. Usually, three successive biopsy cylinders were taken along the target trajectory. Histological examination revealed the prevalence of high-grade non-Hodgkin's lymphoma of the polymorphous centroblastic type. The series did not include any low-grade lymphomas or T-cell lymphomas. L-26 immunohistochemistry resulted in a positive staining of the blasts, thus confirming the B-cell origin of primary brain lymphomas. Small reactive T-lymphocytes and monohistiocytic cells were also found within and at the periphery of the lymphomas and in areas of degeneration. In the biopsies of nine patients, who had shown significant reduction of the lesions on the CT scans, after corticosteroid medication, regressive tissue changes were predominant and consisted of T-lymphocytes, macrophages, and occasionally bizarre reactive astrocytes.
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