ArticleProteomics. Clinical applications2008
Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease.
Article in Proteomics. Clinical applications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Plasma Biomarkers: Potent Screeners of Alzheimer's Disease.American journal of Alzheimer's disease and other dementias · 2019Review
- Mass synaptometry: High-dimensional multi parametric assay for single synapses.Journal of neuroscience methods · 2019Article
- Hungry Neurons: Metabolic Insights on Seizure Dynamics.International journal of molecular sciences · 2017Review
- Closing the gap between brain banks and proteomics to advance the study of neurodegenerative diseases.Proteomics. Clinical applications · 2015Article
- Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery.Biochimica et biophysica acta · 2015Article
- Redox proteomics in selected neurodegenerative disorders: from its infancy to future applications.Antioxidants & redox signaling · 2012Review
- 4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies.Antioxidants & redox signaling · 2012Review
- Biomarkers for cognitive impairment in Parkinson disease.Brain pathology (Zurich, Switzerland) · 2010Review
- Biomarker discovery in neurodegenerative diseases: a proteomic approach.Neurobiology of disease · 2009Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Proteomics has revealed itself as a powerful tool in the identification and determination of proteins and their biological significance. More recently, several groups have taken advantage of the high-throughput nature of proteomics in order to gain a more in-depth understanding of the human brain. In turn, this information has provided researchers with invaluable insight into the potential pathways and mechanisms involved in the pathogenesis of several neurodegenerative disorders, e.g., Alzheimer and Parkinson disease. Furthermore, these findings likely will improve methods to diagnose disease and monitor disease progression as well as generate novel targets for therapeutic intervention. Despite these advances, comprehensive understanding of the human brain proteome remains challenging, and requires development of improved sample enrichment, better instrumentation, and innovative analytic techniques. In this review, we will focus on the most recent progress related to identification of proteins in the human brain under normal as well as pathological conditions, mainly Alzheimer and Parkinson disease, their potential application in biomarker discovery, and discuss current advances in protein identification aimed at providing a more comprehensive understanding of the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.