Trial reportMolecular imaging and biology2011
Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administration.
Trial report in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Trial
- Quantifying Olfactory and Alveolar Deposition of Ultrafine Particles Using Multiscale Modeling: Implications for Brain Exposure.Environmental science & technology · 2026Article
- Comparative Analysis of Micrometer-Sized Particle Deposition in the Olfactory Regions of Adult and Pediatric Nasal Cavities: A Computational Study.Pharmaceutics · 2024Article
- Intranasal delivery of imaging agents to the brain.Theranostics · 2024Review
- Clinical significance of olfactory dysfunction in patients of COVID-19.Journal of the Chinese Medical Association : JCMA · 2021Review
- Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo.Molecular neurobiology · 2020Article
- Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study.Molecules (Basel, Switzerland) · 2020Article
- Olfactory Bulb Magnetic Resonance Imaging in SARS-CoV-2-Induced Anosmia: The First Report.Academic radiology · 2020Article
- Imaging of intranasal drug delivery to the brain.American journal of nuclear medicine and molecular imaging · 2020Review
- Nasal thallium-201 uptake in patients with parosmia with and without hyposmia after upper respiratory tract infection.International forum of allergy & rhinology · 2019Article
- Correlation of regional deposition dosage for inhaled nanoparticles in human and rat olfactory.Particle and fibre toxicology · 2019Article
- Functional Olfactory Nerve Regeneration Demonstrated by Thallium-201 Olfacto-Scintigraphy in Patients with Traumatic Anosmia: A Case Report.Case reports in otolaryngology · 2019Article
- Morphological evaluation using MRI of the olfactory filaments (fila) in a post-traumatic olfactory rat model.World journal of otorhinolaryngology - head and neck surgery · 2018Article
- Olfactory dysfunction revisited: a reappraisal of work-related olfactory dysfunction caused by chemicals.Journal of occupational medicine and toxicology (London, England) · 2018Review
- Pharmacoimaging of Blood-Brain Barrier Permeable (FDG) and Impermeable (FLT) Substrates After Intranasal (IN) Administration.The AAPS journal · 2017Article
- Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction.Scientific reports · 2017Article
- Olfactory deposition of inhaled nanoparticles in humans.Inhalation toxicology · 2015Article
- Neurological impacts from inhalation of pollutants and the nose-brain connection.Neurotoxicology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration. PROCEDURES: Healthy volunteers were enrolled in this study after giving informed consent (five males, 35-51 years old). The subjects were nasally administered (201)TlCl into either the olfactory cleft. Twenty-four hours later, uptake of (201)Tl was detected by a single photon emission computed tomography (SPECT)/X-ray computed tomography hybrid system. For each subject, an MRI image was obtained and merged with the SPECT image.
resultsThe peak of the (201)Tl uptake entered into the olfactory bulb in the anterior skull base through the cribriform lamina 24 h after nasal administration of (201)Tl. No participant had olfactory disturbance after treatment.
conclusionsNasal (201)Tl administration was safely used to assess the direct pathway to the brain via the nose in healthy volunteers with normal olfactory threshold.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.