ArticleNeurochemical research2010
Brain energy metabolism during experimental neonatal seizures.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Glioma region-specific metabolites associated with patient seizures.Journal of neuro-oncology · 2026Article
- Review
- The metabolic overdrive hypothesis: hyperglycolysis and glutaminolysis in bipolar mania.Molecular psychiatry · 2024Article
- Integrating metabolomics and lipidomics revealed a decrease in plasma fatty acids but an increase in triglycerides in children with drug-refractory epilepsy.Epilepsia open · 2023Article
- Potential role of creatine as an anticonvulsant agent: evidence from preclinical studies.Frontiers in neuroscience · 2023Review
- A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore.PloS one · 2022Article
- Changes in lipid profiles of epileptic mouse model.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2020Review
- Mitochondrial dysfunction and role in spreading depolarization and seizure.Journal of computational neuroscience · 2019Article
- Review
- Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy.Free radical biology & medicine · 2018Article
- Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-traumatic Epilepsy.Frontiers in cellular neuroscience · 2018Review
- Proconvulsant effects of the ketogenic diet in electroshock-induced seizures in mice.Metabolic brain disease · 2017Article
- Dynamic transition of neuronal firing induced by abnormal astrocytic glutamate oscillation.Scientific reports · 2016Article
- CNF1 Enhances Brain Energy Content and Counteracts Spontaneous Epileptiform Phenomena in Aged DBA/2J Mice.PloS one · 2015Article
- A novel, noninvasive, predictive epilepsy biomarker with clinical potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Glucose control during labor and delivery.Current diabetes reports · 2014Review
- PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Glycolysis in energy metabolism during seizures.Neural regeneration research · 2013Review
- The depolarizing action of GABA in cultured hippocampal neurons is not due to the absence of ketone bodies.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
During flurothyl seizures in 4-day-old rats, cortical concentration of ATP, phosphocreatine and glucose fell while lactate rose. Cortical energy use rate more than doubled, while glycolytic rate increased fivefold. Calculation of the cerebral metabolic balance during sustained seizures suggests that energy balance could be maintained in hyperglycemic animals, and would decline slowly in normoglycemia, but would be compromised by concurrent hypoglycemia, hyperthermia or hypoxia. These results suggest that the metabolic challenge imposed on the brain by this model of experimental neonatal seizures is milder than that seen at older ages, but can become critical when associated with other types of metabolic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.