ArticleMammalian genome : official journal of the International Mammalian Genome Society2011
The receptor locus for Escherichia coli F4ab/F4ac in the pig maps distal to the MUC4-LMLN region.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- Genetic resistance confers protection against clinical severity, intestinal colonization, and mortality in weaned pigs experimentally challenged with pathogenic F18 and F4 InPECTranslational animal science · 2026Article
- Outbreaks of post-weaning diarrhea caused by ETEC F4 are strongly associated with CHCF1 genotype in Danish pigs.Scientific reports · 2025Article
- Survey on resistance occurrence for F4Veterinary research communications · 2024Article
- miR-17-3p promotes the proliferation of multiple myeloma cells by downregulating P21 expression through LMLN inhibition.International journal of cancer · 2021Article
- Resistance to ETEC F4/F18-mediated piglet diarrhoea: opening the gene black box.Tropical animal health and production · 2019Review
- Identification of porcine CTLA4 gene polymorphism and their association with piglet diarrhea and performance traits.Molecular biology reports · 2019Article
- Article
- Piglet gut microbial shifts early in life: causes and effects.Journal of animal science and biotechnology · 2019Review
- Assessment of Autozygosity Derived From Runs of Homozygosity in Jinhua Pigs Disclosed by Sequencing Data.Frontiers in genetics · 2019Article
- Effect of mucin 4 allele on susceptibility to experimental infection with enterotoxigenic F4Journal of animal science and biotechnology · 2019Article
- Review
- Animal Enterotoxigenic Escherichia coli.EcoSal Plus · 2016Review
- Porcine aminopeptidase N binds to F4+ enterotoxigenic Escherichia coli fimbriae.Veterinary research · 2016Article
- Oral administration of a select mixture of Bacillus probiotics generates Tr1 cells in weaned F4ab/acR- pigs challenged with an F4+ ETEC/VTEC/EPEC strain.Veterinary research · 2015Article
- Refined candidate region for F4ab/ac enterotoxigenic Escherichia coli susceptibility situated proximal to MUC13 in pigs.PloS one · 2014Article
- Virulence profiles of enterotoxigenic, shiga toxin and enteroaggregative Escherichia coli in South African pigs.Tropical animal health and production · 2013Article
- Gene silencing of porcine MUC13 and ITGB5: candidate genes towards Escherichia coli F4ac adhesion.PloS one · 2013Article
- The search for the gene mutations underlying enterotoxigenic Escherichia coli F4ab/ac susceptibility in pigs: a review.Veterinary research · 2012Review
- Differential gene expression profiling of porcine epithelial cells infected with three enterotoxigenic Escherichia coli strains.BMC genomics · 2012Article
- Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs.PloS one · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterotoxigenic Escherichia coli (ETEC) with fimbriae of the F4 family are one of the major causes of diarrhea and death among neonatal and young piglets. Bacteria use the F4 fimbriae to adhere to specific receptors expressed on the surface of the enterocytes. F4 fimbriae exist in three different antigenic variants, F4ab, F4ac, and F4ad, of which F4ac is the most common. Resistance to ETEC F4ab/F4ac adhesion in pigs has been shown to be inherited as an autosomal recessive trait. In previous studies the ETEC F4ab/F4ac receptor locus (F4bcR) was mapped to the q41 region on pig chromosome 13. A polymorphism within an intron of the mucin 4 (MUC4) gene, which is one of the possible candidate genes located in this region, was shown earlier to cosegregate with the F4bcR alleles. Recently, we discovered a Large White boar from a Swiss experimental herd with a recombination between F4bcR and MUC4. A three-generation pedigree including 45 offspring was generated with the aim to use this recombination event to refine the localization of the F4bcR locus. All pigs were phenotyped using the microscopic adhesion test and genotyped for a total of 59 markers. The recombination event was mapped to a 220-kb region between a newly detected SNP in the leishmanolysin-like gene (LMLN g.15920) and SNP ALGA0072075. In this study the six SNPs ALGA0072075, ALGA0106330, MUC13-226, MUC13-813, DIA0000584, and MARC0006918 were in complete linkage disequilibrium with F4bcR. Based on this finding and earlier investigations, we suggest that the locus for F4bcR is located between the LMLN locus and microsatellite S0283.
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