ReviewNature reviews. Rheumatology2011
Getting arthritis gene therapy into the clinic.
Review in Nature reviews. Rheumatology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 68 citations in OpenAlex.
- Genetic applications in arthroplasty: A review.Bulletin of the Hospital for Joint Disease (2013) · 2025Review
- Development of a macrophage polarization-modulating therapeutic agent for osteoarthritis treatment.Journal of orthopaedic surgery and research · 2025Review
- Therapeutic Controlled Release Strategies for Human Osteoarthritis.Advanced healthcare materials · 2025Review
- Lentiviral Production Platform.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Lentiviral-Mediated Systemic RNA Interference In Vivo.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Orthopaedic Gene Therapy: Twenty-Five Years On.JBJS reviews · 2021Article
- Design, Preparation, and Bioactivity Study of New Fusion Protein HB-NC4 in the Treatment of Osteoarthritis.Frontiers in bioengineering and biotechnology · 2021Article
- Article
- Potential mechanisms of action of celastrol against rheumatoid arthritis: Transcriptomic and proteomic analysis.PloS one · 2020Article
- Targeting the extracellular matrix for delivery of bioactive molecules to sites of arthritis.British journal of pharmacology · 2019Review
- Gene Delivery to Joints by Intra-Articular Injection.Human gene therapy · 2018Review
- Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis.International journal of molecular sciences · 2016Review
- Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes.Experimental and therapeutic medicine · 2016Article
- Treatment of osteoarthritis using a helper-dependent adenoviral vector retargeted to chondrocytes.Molecular therapy. Methods & clinical development · 2016Article
- Current research on pharmacologic and regenerative therapies for osteoarthritis.Bone research · 2016Review
- scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy.Gene therapy · 2015Article
- Gene therapy approaches to regenerating the musculoskeletal system.Nature reviews. Rheumatology · 2015Review
- Biologics for tendon repair.Advanced drug delivery reviews · 2015Review
- Spatial regulation of controlled bioactive factor delivery for bone tissue engineering.Advanced drug delivery reviews · 2015Review
- Cytokine-modulating strategies and newer cytokine targets for arthritis therapy.International journal of molecular sciences · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Gene transfer technologies enable the controlled, targeted and sustained expression of gene products at precise anatomical locations, such as the joint. In this way, they offer the potential for more-effective, less-expensive treatments of joint diseases with fewer extra-articular adverse effects. A large body of preclinical data confirms the utility of intra-articular gene therapy in animal models of rheumatoid arthritis and osteoarthritis. However, relatively few clinical trials have been conducted, only one of which has completed phase II. This article summarizes the status in 2010 of the clinical development of gene therapy for arthritis, identifies certain constraints to progress and suggests possible solutions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.