Evidence map›Paper›PMID 21135876›Full record

ReviewNature reviews. Urology2011

Urinary and sexual dysfunction after rectal cancer treatment.

Marilyne M Lange, Cornelis J H van de Velde

2 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01912586 phase4completednot on this mapstarted 2013, after this paper: background citation

A Non-randomised Controlled Trial of Early Intervention to Preserve Erectile Function After Laparoscopic Resection for Rectal Cancer

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2013 to 2015Enrolled90ConditionsRectal Tumors, Erectile DysfunctionArmsvacuum erection device
NCT06435975 nacompletednot on this mapstarted 2022, after this paper: background citation

Pilot Study of Physical Activity Intervention to Manage Bowel Dysfunction in Rectal Cancer Survivors

TypeinterventionalSponsorAbramson Cancer Center at Penn MedicineRan2022 to 2024Enrolled20ConditionsRectal Cancer, Rectosigmoid CancerArmsPhysical Activity, Survey, Telehealth Lifestyle Coaching
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  11. Does the level of inferior mesenteric artery ligation affect outcomes in rectal cancer: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  16. Utilizing Patient Input in Rectal Cancer Trial Design.Journal of the National Cancer Institute · 2025
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marilyne M LangeDepartment of Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Cornelis J H van de Velde

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In light of the improving prognosis for patients with rectal cancer, the quality of functional outcome has become increasingly important. Despite the good functional results achieved by expert surgeons, large multicenter studies show that urogenital dysfunction remains a common problem after rectal cancer treatment. More than half of patients experience a deterioration in sexual function, consisting of ejaculatory problems and impotence in men and vaginal dryness and dyspareunia in women. Urinary dysfunction occurs in one-third of patients treated for rectal cancer. Surgical nerve damage is the main cause of urinary dysfunction. Radiotherapy seems to have a role in the development of sexual dysfunction, without affecting urinary function. Pelvic autonomic nerves are especially at risk in cases of low rectal cancer and during abdominoperineal resection. Data concerning nerve damage during laparoscopic surgery for resection of rectal cancer are awaited. Structured education of surgeons with regard to pelvic neuroanatomy, and systematic registration of identified nerves, could well be the key to improving functional outcome for these patients. Meanwhile, patients should be informed of all associated risks before their operation, and their functional status should be evaluated before and after surgery.

Indexed as

Digestive System Surgical ProceduresHumansRectal NeoplasmsSexual Dysfunction, PhysiologicalUrination Disorders

Identifiers

PMID21135876

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.