ReviewMolecules (Basel, Switzerland)2010
Thiol signalling network with an eye to diabetes.
Review in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 105 citations in OpenAlex.
- Effect of maternal body mass index on inflammatory biomarkers and dynamic thiol-disulfide homeostasis during pregnancy.BMC pregnancy and childbirth · 2025Article
- Changes in Dynamic Thiol/Disulfide Homeostasis, and Substance P, B-Endorphin and α-Tocopherol Concentrations in the Spinal Cord of Chronically Lame Dairy Cows.Animals : an open access journal from MDPI · 2023Article
- Circulating Biomarkers to Predict Diabetic Retinopathy in Patients with Diabetic Kidney Disease.Vision (Basel, Switzerland) · 2023Review
- Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Association of thiol/disulphide homeostasis with Bethesda classification of thyroid nodules and thyroid cancer.Turkish journal of medical sciences · 2022Article
- Assessing Oxidative Stress by Thiol/Disulfide Homeostasis Among Vitamin D-Deficient Patients.Cureus · 2021Article
- Simultaneous Determination of Human Serum Albumin and Low-Molecular-Weight Thiols after Derivatization with Monobromobimane.Molecules (Basel, Switzerland) · 2021Article
- Evaluation of Thiol Homeostasis in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.Frontiers in neurology · 2021Article
- Oxidative stress parameters in patients with ascending aortic dilatationTurkish journal of medical sciences · 2020Article
- The Significance of Thiol/Disulfide Homeostasis and Ischemia-modified Albumin Levels in Assessing Oxidative Stress in Obese Children and AdolescentsJournal of clinical research in pediatric endocrinology · 2020Article
- An investigation of thiol/disulfide homeostasis in patients with Behçet's disease.Archives of medical science : AMS · 2020Article
- An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves' Disease.Medicina (Kaunas, Lithuania) · 2019Article
- Dynamic thiol/disulfide homeostasis in patients with lichen planus.Journal of clinical laboratory analysis · 2019Article
- A Study Over Thiol Disulfide Homeostasis in Cord Blood in Women With Gestational Diabetes.Journal of family & reproductive health · 2018Article
- Plasma Ischemia-Modified Albumin Levels and Dynamic Thiol/Disulfide Balance in Sickle Cell Disease: A Case-Control StudyTurkish journal of haematology : official journal of Turkish Society of Haematology · 2018Article
- Investigation of dynamic thiol-disulphide homoeostasis in age-related cataract patients with a novel and automated assay.International ophthalmology · 2018Article
- A novel marker in acute central serous chorioretinopathy: thiol/disulfide homeostasis.International ophthalmology · 2018Article
- Dynamic Thiol/Disulphide Homeostasis in Patients With Fibromyalgia.Archives of rheumatology · 2017Article
- Thiol/disulphide homeostasis in celiac disease.World journal of gastrointestinal pharmacology and therapeutics · 2017Article
- Thiol/disulfide homeostasis in patients with ankylosing spondylitis.Bosnian journal of basic medical sciences · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Redox regulatory system controls normal cellular functions. Controlled changes in redox couples potential serve as components for signal transduction, similarly to the phosphorylation cascade. Cellular redox biology requires both compartimentalisation and communication of redox systems: the thermodynamic disequilibrium of the major redox switches allows rapid and sensitive responses to perturbations in redox environments. The many oxidation states of sulphur are found in numerous sulphur species with distinct functional groups (thiols, disulphides, polysulphides, sulphenic, sulphinic and sulphonic acids, etc.), which participate in a complicated network of sulphur-based redox events. Human diseases such as diabetes mellitus and its cardiovascular complications have been associated with increased production of reactive oxygen species and perturbations of thiol redox homeostasis. The review surveys literature related to some etiopathogenic aspects and therapeutic perspectives. The dual toxic-protective property of sulphydryl-donor molecules in experimental settings proposes the general problem of designing antioxidants for therapeutic use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.