ArticleThe Journal of clinical investigation2011
Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 60 citations in OpenAlex.
- The Role of β-Core Fragment hCG in Embryo Implantation and Early Pregnancy.International journal of molecular sciences · 2025Article
- The mutation of NSUN5 R295C promotes preeclampsia by impairing decidualization through downregulating IL-11Rα.iScience · 2024Article
- Lipopolysaccharides ofToxins · 2023Article
- Decidualization and Related Pregnancy Complications.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
- miR-378d suppresses malignant phenotype of ESCC cells through AKT signaling.Cancer cell international · 2021Article
- Effects of Aurora kinase A on mouse decidualization via Stat3-plk1-cdk1 pathway.Reproductive biology and endocrinology : RB&E · 2021Article
- Genome-wide scan highlights the role of candidate genes on phenotypic plasticity for age at first calving in Nellore heifers.Scientific reports · 2020Article
- Metabolism-induced oxidative stress and DNA damage selectively trigger genome instability in polyploid fungal cells.The EMBO journal · 2019Article
- Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer.Nature communications · 2019Article
- The origins and functions of hepatic polyploidy.Cell cycle (Georgetown, Tex.) · 2019Review
- Molecular mechanisms of embryonic implantation in mammals: Lessons from the gene manipulation of mice.Reproductive medicine and biology · 2018Review
- Inside the Endometrial Cell Signaling Subway: Mind the Gap(s).International journal of molecular sciences · 2018Review
- Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia.Molecular medicine reports · 2017 · on this mapArticle
- The decidua-the maternal bed embracing the embryo-maintains the pregnancy.Seminars in immunopathology · 2016Review
- MCM2 mediates progesterone-induced endometrial stromal cell proliferation and differentiation in mice.Endocrine · 2016Article
- Polycomb repressive complex 1 controls uterine decidualization.Scientific reports · 2016Article
- Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3.Scientific reports · 2015Article
- Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells.Reproductive biology and endocrinology : RB&E · 2015Article
- Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.Cell cycle (Georgetown, Tex.) · 2015Article
- The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice.Biology of reproduction · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During intrauterine life, the mammalian embryo survives via its physical connection to the mother. The uterine decidua, which differentiates from stromal cells after implantation in a process known as decidualization, plays essential roles in supporting embryonic growth before establishment of the placenta. Here we show that female mice lacking death effector domain-containing protein (DEDD) are infertile owing to unsuccessful decidualization. In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was subsequently accompanied by disintegration of implantation site structure, leading to embryonic death before placentation. Polyploidization, a hallmark of mature decidual cells, was attenuated in DEDD-deficient cells during decidualization. Such inefficient decidualization appeared to be caused by decreased Akt levels, since polyploidization was restored in DEDD-deficient decidual cells by overexpression of Akt. In addition, we showed that DEDD associates with and stabilizes cyclin D3, an important element in polyploidization, and that overexpression of cyclin D3 in DEDD-deficient cells improved polyploidization. These results indicate that DEDD is indispensable for the establishment of an adequate uterine environment to support early pregnancy in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.