ArticleHypertension (Dallas, Tex. : 1979)2011
Blood pressure and cerebral white matter share common genetic factors in Mexican Americans.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
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- Towards the multileveled and processual conceptualisation of racialised individuals in biomedical research.Synthese · 2023Article
- The additive impact of cardio-metabolic disorders and psychiatric illnesses on accelerated brain aging.Human brain mapping · 2022Article
- White matter and hypoxic hypobaria in humans.Human brain mapping · 2019Article
- Blood Pressure Control and Protection of the Aging Brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Genomic kinship construction to enhance genetic analyses in the human connectome project data.Human brain mapping · 2019Article
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.Obesity (Silver Spring, Md.) · 2017Article
- White matter disease in midlife is heritable, related to hypertension, and shares some genetic influence with systolic blood pressure.NeuroImage. Clinical · 2016Article
- Shared genetic variance between obesity and white matter integrity in Mexican Americans.Frontiers in genetics · 2015Article
- Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.Human brain mapping · 2014Article
- Accelerated white matter aging in schizophrenia: role of white matter blood perfusion.Neurobiology of aging · 2014Article
- Multimodal white matter imaging to investigate reduced fractional anisotropy and its age-related decline in schizophrenia.Psychiatry research · 2014Article
- Lower neurocognitive function in U-2 pilots: Relationship to white matter hyperintensities.Neurology · 2014Article
- Neurodevelopmental and neurodegenerative models of schizophrenia: white matter at the center stage.Schizophrenia bulletin · 2014Review
- A Neuregulin-1 schizophrenia susceptibility variant causes perihippocampal fiber tract anomalies in healthy young subjects.Brain and behavior · 2014Article
- Different locations but common associations in subcortical hypodensities of presumed vascular origin: cross-sectional study on clinical and neurosonologic correlates.BMC neurology · 2014Article
- Corpus callosum size is highly heritable in humans, and may reflect distinct genetic influences on ventral and rostral regions.PloS one · 2014Article
- Small vessel disease and memory loss: what the clinician needs to know to preserve patients' brain health.Current cardiology reports · 2013Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Elevated arterial pulse pressure and blood pressure (BP) can lead to atrophy of cerebral white matter (WM), potentially attributable to shared genetic factors. We calculated the magnitude of shared genetic variance between BP and fractional anisotropy of water diffusion, a sensitive measurement of WM integrity in a well-characterized population of Mexican Americans. The patterns of whole-brain and regional genetic overlap between BP and fractional anisotropy were interpreted in the context the pulse-wave encephalopathy theory. We also tested whether regional pattern in genetic pleiotropy is modulated by the phylogeny of WM development. BP and high-resolution (1.7 × 1.7 × 3 mm; 55 directions) diffusion tensor imaging data were analyzed for 332 (202 females; mean age 47.9 ± 13.3 years) members of the San Antonio Family Heart Study. Bivariate genetic correlation analysis was used to calculate the genetic overlap between several BP measurements (pulse pressure, systolic BP, and diastolic BP) and fractional anisotropy (whole-brain and regional values). Intersubject variance in pulse pressure and systolic BP exhibited a significant genetic overlap with variance in whole-brain fractional anisotropy values, sharing 36% and 22% of genetic variance, respectively. Regionally, shared genetic variance was significantly influenced by rates of WM development (r=-0.75; P=0.01). The pattern of genetic overlap between BP and WM integrity was generally in agreement with the pulse-wave encephalopathy theory. Our study provides evidence that a set of pleiotropically acting genetic factors jointly influence phenotypic variation in BP and WM integrity. The magnitude of this overlap appears to be influenced by phylogeny of WM development, suggesting a possible role for genotype-by-age interactions.
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