ArticleJournal of dental research2011
Inflammation and uncoupling as mechanisms of periodontal bone loss.
Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
145 citing papers in PubMed, 2 syntheses or guidelines pooled it, 280 citations in OpenAlex.
- Association of vitamin D in individuals with periodontitis: an updated systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis.Clinical oral investigations · 2019Pooled it
- Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial.Clinical oral investigations · 2025Trial
- Inflammatory and bone remodelling related biomarkers following periodontal transplantation of the tissue engineered biocomplex.Clinical oral investigations · 2024Trial
- Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease.Scientific reports · 2021Trial
- Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis.PloS one · 2018Trial
- High-dose atorvastatin reduces periodontal inflammation: a novel pleiotropic effect of statins.Journal of the American College of Cardiology · 2013Trial
- Oral Piercing in the Aspect of Periodontal and Dental Health-A Narrative Review.Journal of clinical medicine · 2026Review
- USAG-1/SOSTDC1 as a Candidate Target for Periodontal Regeneration: Biological Rationale, Knowledge Gaps, and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- Periodontal and Peri-Implant Status Among Users of Different Inhaled Tobacco and Nicotine Products: A Systematic Review.Dentistry journal · 2026Review
- Article
- Comorbidities and Inflammation: How Chronic Diseases Prime the Host Response in Sepsis.International journal of molecular sciences · 2026Review
- From Caries to Periodontal Breakdown: A Biological and Clinical Continuum Linking Cariology, Operative Dentistry, Endodontics, and Periodontology.Dentistry journal · 2026Review
- Laser-Based Photobiomodulation for Orthodontic Pain: Mechanistic Evidence from Experimental Tooth-Movement Models.International journal of molecular sciences · 2026Review
- Comparative Effects ofInternational journal of molecular sciences · 2026Article
- Article
- Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.Journal of periodontal research · 2026Review
- Article
- CD169Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies.Bone research · 2026Review
85 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Periodontal disease is characterized by both inflammation and bone loss. Advances in research in both these areas have led to a new appreciation of not only each field but also the intimate relationship between inflammation and bone loss. This relationship has resulted in a new field of science called osteoimmunology and provides a context for better understanding the pathogenesis of periodontal disease. In this review, we discuss several aspects of the immuno-inflammatory host response that ultimately results in loss of alveolar bone. A proposal is made that periodontal inflammation not only stimulates osteoclastogenesis but also interferes with the uncoupling of bone formation and bone resorption, consistent with a pathologic process. Furthermore, arguments based on experimental animal models suggest a critical role of the spatial and temporal aspects of inflammation in the periodontium. A review of these findings leads to a new paradigm to help explain more fully the impact of inflammation on alveolar bone in periodontal disease so that it includes the effects of inflammation on uncoupling of bone formation from resorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.