ArticleDisease models & mechanisms2011
RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.
Article in Disease models & mechanisms, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Liver Kinase B1 Functions as a Regulator for Neural Development and a Therapeutic Target for Neural Repair.Cells · 2022Review
- Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans.Multiple sclerosis and related disorders · 2021Article
- Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis.Glia · 2020Article
- A comprehensive systematic review of CSF proteins and peptides that define Alzheimer's disease.Clinical proteomics · 2020Review
- Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis.Frontiers in molecular neuroscience · 2018Article
- Peripheral Neuropathy and Hindlimb Paralysis in a Mouse Model of Adipocyte-Specific Knockout of Lkb1.EBioMedicine · 2017Article
- A Larger BAT Improves Metabolism but Whiffs on Safety.EBioMedicine · 2017Article
- BAT Expansion: A Panacea against Obesity? Lessons from LKB1.EBioMedicine · 2017Article
- The transcription factorThe Journal of biological chemistry · 2017Article
- Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice.Frontiers of medicine · 2016Article
- Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.Biochimica et biophysica acta · 2016Review
- The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.Cell calcium · 2016Article
- LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration.Scientific reports · 2015Article
- LKB1 Is Required for the Development and Maintenance of Stereocilia in Inner Ear Hair Cells in Mice.PloS one · 2015Article
- The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.Disease models & mechanisms · 2014Article
- LKB1 and AMPK differentially regulate pancreatic β-cell identity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells.BMC cancer · 2014Article
- Animal models of GWAS-identified type 2 diabetes genes.Journal of diabetes research · 2013Review
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4 authors at 2 institutions in 2 countries.
Funding
Abstract
Axon degeneration is observed in neurodegenerative diseases and neuroinflammatory disorders, such as Alzheimer's disease, Parkinson's disease and multiple sclerosis. The molecular basis of this process remains largely unknown. Here, we show that mice deleted for the tumour suppressor LKB1 (also called STK11) in the spinal cord, some parts of the brain and in the endocrine pancreas (βLKB1KO mice) develop hind-limb dysfunction and axon degeneration at about 7 weeks. Demyelination and macrophage infiltration are observed in the white matter of these mice, predominantly in the bilateral and anterior funiculi of the thoracic segment of the spinal cord, suggesting damage to the ascending sensory signalling pathway owing to LKB1 deletion in the brain. Microtubule structures were also affected in the degenerated foci, with diminished neurofilament and tubulin expression. Deletion of both PRKAA1 genes, whose products AMPKα1 and AMPKα2 are also downstream targets of LKB1, with the same strategy was without effect. We thus define LKB1 as an intrinsic suppressor of axon degeneration and a possible target for strategies that can reverse this process.
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Registered trials
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