Evidence map›Paper›PMID 21135051›Full record

Trial reportThe Journal of physiology2011

Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle.

Niels Ørtenblad, Joachim Nielsen, Bengt Saltin, Hans-Christer Holmberg

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 6 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 6 syntheses or guidelines pooled it, 206 citations in OpenAlex.

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  13. Acute Maltodextrin Supplementation During Resistance Exercise.Journal of sports science & medicine · 2020
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Niels ØrtenbladInstitute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense M, Denmark. nortenblad@health.sdu.dk
Joachim Nielsen
Bengt Saltin
Hans-Christer Holmberg
University of Southern Denmark · DKSwedish Olympic Committee · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucose is stored as glycogen in skeletal muscle. The importance of glycogen as a fuel during exercise has been recognized since the 1960s; however, little is known about the precise mechanism that relates skeletal muscle glycogen to muscle fatigue. We show that low muscle glycogen is associated with an impairment of muscle ability to release Ca(2+), which is an important signal in the muscle activation. Thus, depletion of glycogen during prolonged, exhausting exercise may contribute to muscle fatigue by causing decreased Ca(2+) release inside the muscle. These data provide indications of a signal that links energy utilization, i.e. muscle contraction, with the energy content in the muscle, thereby inhibiting a detrimental depletion of the muscle energy store.

Indexed as

AdultAthletesBiopsy, NeedleCalciumCresolsDietary CarbohydratesGlycogenHumansKineticsLactic AcidMaleMicroscopy, Electron, TransmissionMuscle FatigueMuscle Fibers, SkeletalMuscle, SkeletalMyofibrilsCalciumchlorocresolCresolsDietary CarbohydratesGlycogenLactic AcidMyosin Heavy Chains

Identifiers

PMID21135051
PMCPMC3055553
OpenAlexW1558831010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.