Trial reportThe Journal of physiology2011
Skeletal muscle fatigue precedes the slow component of oxygen uptake kinetics during exercise in humans.
Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Regional tissue oxygenation during high-intensity exercise following voluntary isocapnic hyperpnea versus inspiratory threshold loading in endurance-trained individuals: a randomized controlled trial.Scientific reports · 2026Trial
- A randomized, crossover, placebo controlled, double-blind trial of the effects of tiotropium-olodaterol on neuromuscular performance during exercise in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training.PloS one · 2016Trial
- vΔ50 Race Walking: High Energetic Cost, Rapid VOJournal of functional morphology and kinesiology · 2026Article
- Impaired oxygen consumption kinetics and autonomic dysfunction contribute to increased fatigue in obese young males during sustained exercise.Journal of exercise rehabilitation · 2025Article
- Muscle fatigue, pedalling technique and theExperimental physiology · 2025Article
- The validity and reliability of quadriceps twitch force as a measure of skeletal muscle fatigue while cycling.European journal of sport science · 2024Article
- Oxygen Uptake and Bilaterally Measured Vastus Lateralis Muscle Oxygen Desaturation Kinetics in Well-Trained Endurance Cyclists.Journal of functional morphology and kinesiology · 2023Article
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Energy metabolism and muscle activation heterogeneity explainExperimental physiology · 2023Article
- 'Fatigue makes cowards of us all'.Experimental physiology · 2023Article
- Interaction of Factors Determining Critical Power.Sports medicine (Auckland, N.Z.) · 2023Review
- Toward the Personalization of Biceps Fatigue Detection Model for Gym Activity: An Approach to Utilize Wearables' Data from the Crowd.Sensors (Basel, Switzerland) · 2022Article
- Bioenergetic Mechanisms Linking V˙O2 Kinetics and Exercise Tolerance.Exercise and sport sciences reviews · 2021Article
- Towards Detecting Biceps Muscle Fatigue in Gym Activity Using Wearables.Sensors (Basel, Switzerland) · 2021Article
- Exceeding a "critical" muscle PEuropean journal of applied physiology · 2020Article
- Alterations to neuromuscular properties of skeletal muscle are temporally dissociated from the oxygen uptake slow component.Scientific reports · 2020Article
- Changes in VOFrontiers in physiology · 2019Article
- "Work-to-Work" exercise slows pulmonary oxygen uptake kinetics, decreases critical power, and increases W' during supine cycling.Physiological reports · 2018Article
- Elevated baseline work rate slows pulmonary oxygen uptake kinetics and decreases critical power during upright cycle exercise.Physiological reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms determining exercise intolerance are poorly understood. A reduction in work efficiency in the form of an additional energy cost and oxygen requirement occurs during high-intensity exercise and contributes to exercise limitation. Muscle fatigue and subsequent recruitment of poorly efficient muscle fibres has been proposed to mediate this decline. These data demonstrate in humans, that muscle fatigue, generated in the initial minutes of exercise, is correlated with the increasing energy demands of high-intensity exercise. Surprisingly, however, while muscle fatigue reached a plateau, oxygen uptake continued to increase throughout 8 min of exercise. This suggests that additional recruitment of inefficient muscle fibres may not be the sole mechanism contributing to the decline in work efficiency during high-intensity exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.