ReviewThe Journal of physiology2011
Neo-Darwinism, the modern synthesis and selfish genes: are they of use in physiology?
Review in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 135 citations in OpenAlex.
- A Computational Trial of Dermal Mechanotransduction in GLP-1 Receptor Agonist-Associated Premature Facial Ageing.Aesthetic plastic surgery · 2026Trial
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- New lessons from biology for economics and business: a systems approach to non-market environments.Journal of the Royal Society, Interface · 2024Article
- Review
- Space Biomedicine: A Unique Opportunity to Rethink the Relationships between Physics and Biology.Biomedicines · 2022Article
- Modern physiology vindicates Darwin's dream.Experimental physiology · 2022Review
- KThe Journal of physiology · 2018Article
- The Dynamical Emergence of Biology From Physics: Branching Causation via Biomolecules.Frontiers in physiology · 2018Article
- Was the Watchmaker Blind? Or Was She One-Eyed?Biology · 2017Review
- Why an extended evolutionary synthesis is necessary.Interface focus · 2017Review
- Genomic insights into ayurvedic and western approaches to personalized medicine.Journal of genetics · 2016Review
- A principle of organization which facilitates broad Lamarckian-like adaptations by improvisation.Biology direct · 2015Article
- The trajectory of life. Decreasing physiological network complexity through changing fractal patterns.Frontiers in physiology · 2015Article
- Generating anatomical variation through mutations in networks - implications for evolution.Journal of anatomy · 2014Article
- Evolution evolves: physiology returns to centre stage.The Journal of physiology · 2014Article
- Systems biology approach to developing "systems therapeutics".ACS medicinal chemistry letters · 2014Article
- A theory of biological relativity: no privileged level of causation.Interface focus · 2012Article
- Giant sucking sound: can physiology fill the intellectual void left by the reductionists?Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Systems biology and cancer.Progress in biophysics and molecular biology · 2011Article
- Physiology: alone at the bottom, alone at the top.The Journal of physiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article argues that the gene-centric interpretations of evolution, and more particularly the selfish gene expression of those interpretations, form barriers to the integration of physiological science with evolutionary theory. A gene-centred approach analyses the relationships between genotypes and phenotypes in terms of differences (change the genotype and observe changes in phenotype). We now know that, most frequently, this does not correctly reveal the relationships because of extensive buffering by robust networks of interactions. By contrast, understanding biological function through physiological analysis requires an integrative approach in which the activity of the proteins and RNAs formed from each DNA template is analysed in networks of interactions. These networks also include components that are not specified by nuclear DNA. Inheritance is not through DNA sequences alone. The selfish gene idea is not useful in the physiological sciences, since selfishness cannot be defined as an intrinsic property of nucleotide sequences independently of gene frequency, i.e. the 'success' in the gene pool that is supposed to be attributable to the 'selfish' property. It is not a physiologically testable hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.