ArticleSchizophrenia bulletin2012
Impaired associative inference in patients with schizophrenia.
Article in Schizophrenia bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05910762 (Learning Novel Structure Across Time and Sleep), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Learning Novel Structure Across Time and Sleep
Who cites it
29 citing papers in PubMed.
- Relational Memory in Psychosis: Learning Trajectories and Associative Inference.Schizophrenia bulletin · 2026Article
- Reduced grid-like theta modulation in schizophrenia.Brain : a journal of neurology · 2023Article
- Accurate Confidence and Bayesian Interval Estimation for Non-centrality Parameters and Effect Size Indices.Psychometrika · 2023Article
- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers.Current topics in behavioral neurosciences · 2023Article
- Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.Schizophrenia bulletin · 2021Article
- Relational memory in the early stage of psychotic bipolar disorder.Psychiatry research · 2020Article
- Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia.Brain : a journal of neurology · 2020Article
- Impaired relational memory in the early stage of psychosis.Schizophrenia research · 2019Article
- Impaired associative inference in the early stage of psychosis.Schizophrenia research · 2018Article
- Memory Allocation: Mechanisms and Function.Annual review of neuroscience · 2018Review
- Regionally specific volume deficits along the hippocampal long axis in early and chronic psychosis.NeuroImage. Clinical · 2018Article
- Hippocampus at 25.Hippocampus · 2016Article
- Transitive inference deficits in unaffected biological relatives of schizophrenia patients.Schizophrenia research · 2016Article
- Effectiveness of fast mapping to promote learning in schizophrenia.Schizophrenia research. Cognition · 2016Article
- Memory deficit in patients with schizophrenia and posttraumatic stress disorder: relational vs item-specific memory.Neuropsychiatric disease and treatment · 2016Review
- Functional and Neuroanatomic Specificity of Episodic Memory Dysfunction in Schizophrenia: A Functional Magnetic Resonance Imaging Study of the Relational and Item-Specific Encoding Task.JAMA psychiatry · 2015Article
- Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia.Clinical psychological science : a journal of the Association for Psychological Science · 2015Article
- Developing treatments for cognitive deficits in schizophrenia: the challenge of translation.Journal of psychopharmacology (Oxford, England) · 2015Review
- Genetic basis of a cognitive complexity metric.PloS one · 2015Article
- Theory of mind in utterance interpretation: the case from clinical pragmatics.Frontiers in psychology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The ability to learn, store, and retrieve information about relationships is impaired in schizophrenia. Here, we tested 38 control and 61 schizophrenia subjects for their ability to identify the novel pairing of stimuli, based on associations learned during training. Subjects were trained on 3 sets of paired associates: 30 face-house pairs (H-F1), 30 face-house pairs (H-F2, same house with new face), and 30 face-face pairs (F3-F4). After training, participants were tested on the 3 explicitly trained pair types, as well as 30 new face-face pairs (F1-F2), which could only be linked together via the same house during the H-F1/H-F2 training blocks. Of 99 subjects tested, 37 patients with schizophrenia and 36 age-matched healthy control subjects learned the premise pairs and performed the relational memory test. Healthy control subjects were significantly more accurate in identifying the inferential (F1-F2) pairs than the noninferential (F3-F4) pairs. In contrast, schizophrenia patients were equally accurate on inferential and noninferential pairs, providing evidence for a relational memory deficit in schizophrenia. However, the current version of the associative inference paradigm, suggested by the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia initiative, has limited feasibility, calling into question the generalizability of the findings for the larger schizophrenia population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.