ArticleMicrobes and infection2011
Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.
Article in Microbes and infection, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice.Infection and immunity · 2019Article
- Optimal protection againstProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory.mBio · 2016Review
- CXCR3 blockade protects against Listeria monocytogenes infection-induced fetal wastage.The Journal of clinical investigation · 2015Article
- Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development.European journal of immunology · 2015Article
- Immunity to intestinal pathogens: lessons learned from Salmonella.Immunological reviews · 2014Review
- MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection.Immunology letters · 2012Article
- Identification of a common immune signature in murine and human systemic Salmonellosis.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Selective culling of high avidity antigen-specific CD4+ T cells after virulent Salmonella infection.Immunology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Typhoid fever is a systemic, persistent infection caused by host-specific strains of Salmonella. Although the use of antibiotics has reduced the complications associated with primary infection, recurrent infection remains an important cause of ongoing human morbidity and mortality. Herein, we investigated the impacts of antibiotic eradication of primary infection on protection against secondary recurrent infection. Using a murine model of persistent Salmonella infection, we demonstrate protection against recurrent infection is sustained despite early eradication of primary infection. In this model, protection is not mediated by CD4(+) or CD8(+) T cells because depletion of these cells either alone or in combination prior to rechallenge does not abrogate protection. Instead, infection followed by antibiotic-mediated clearance primes robust levels of Salmonella-specific antibody that can adoptively transfer protection to naïve mice. Thus, eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.