ArticleNeuroscience letters2011
Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety.Nature neuroscience · 2024Article
- Meranzin Hydrate Improves Depression-Like Behaviors and Hypomotility via Ghrelin and Neurocircuitry.Chinese journal of integrative medicine · 2023Article
- Applications in Awake Animal Magnetic Resonance Imaging.Frontiers in neuroscience · 2022Review
- Mapping stress networks using functional magnetic resonance imaging in awake animals.Neurobiology of stress · 2018Review
- Development of brain-wide connectivity architecture in awake rats.NeuroImage · 2018Article
- Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal.NeuroImage · 2017Review
- Imaging learned fear circuitry in awake mice using fMRI.The European journal of neuroscience · 2015Article
- Cocaine-conditioned odor cues without chronic exposure: Implications for the development of addiction vulnerability.NeuroImage. Clinical · 2015Article
- Article
- The power of using functional fMRI on small rodents to study brain pharmacology and disease.Frontiers in pharmacology · 2015Review
- Neuroplasticity to a single-episode traumatic stress revealed by resting-state fMRI in awake rats.NeuroImage · 2014Article
- Brain processing of biologically relevant odors in the awake rat, as revealed by manganese-enhanced MRI.PloS one · 2012Article
- Can Functional Magnetic Resonance Imaging Improve Success Rates in CNS Drug Discovery?Expert opinion on drug discovery · 2011Article
- An in vivo MRI Template Set for Morphometry, Tissue Segmentation, and fMRI Localization in Rats.Frontiers in neuroinformatics · 2011Article
- The Neurological Ecology of Fear: Insights Neuroscientists and Ecologists Have to Offer one Another.Frontiers in behavioral neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Previous human imaging studies used facial stimuli to explore the potential association between depression and fear. This study aimed at investigating brain alterations in a rodent model of depression when innate fear was induced in the form of the predator odor trimethylthiazoline (TMT). Flinders sensitive line (FSL) rats, a genetic animal model of depression, and their control counterpart Flinders resistant line (FRL), were used in this functional magnetic resonance imaging (fMRI) assessment. Compared to FRL, FSL rats exhibited greater BOLD activation in the cortical amygdala and hypoactivation in the prefrontal cortex in response to TMT, suggesting cortico-amygdalar dysfunction in the depressed strain. In addition, the hyperactivation in the insular cortex in FSL rats may be the basis for enhanced neuronal responses to fear and aversion in depression. These results are evidence for the value of translational models of depression in expanding understanding of the neural circuitries sub-serving common human co-morbidities like depression and fear.
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