ArticleToxicology and applied pharmacology2011
MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury.
Article in Toxicology and applied pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals.Archives of toxicology · 2022Review
- Glutathione-coordinated metal complexes as substrates for cellular transporters.Metallomics : integrated biometal science · 2021Review
- MRP2 and the Transport Kinetics of Cysteine Conjugates of Inorganic Mercury.Biological trace element research · 2018Article
- Xenobiotic transporters and kidney injury.Advanced drug delivery reviews · 2017Review
- Mechanisms involved in the transport of mercuric ions in target tissues.Archives of toxicology · 2017Review
- Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice.Environmental health perspectives · 2016Article
- Toxicological significance of renal Bcrp: Another potential transporter in the elimination of mercuric ions from proximal tubular cells.Toxicology and applied pharmacology · 2015Article
- Novel Hg2+-induced nephropathy in rats and mice lacking Mrp2: evidence of axial heterogeneity in the handling of Hg2+ along the proximal tubule.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.Journal of neurochemistry · 2014Article
- Polymorphisms in ABC transporter genes and concentrations of mercury in newborns--evidence from two Mediterranean birth cohorts.PloS one · 2014Article
- Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse.PloS one · 2013Article
- The role of the Keap1/Nrf2 pathway in the cellular response to methylmercury.Oxidative medicine and cellular longevity · 2013Review
- Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining.Environmental health perspectives · 2013Article
- Placental and fetal disposition of mercuric ions in rats exposed to methylmercury: role of Mrp2.Reproductive toxicology (Elmsford, N.Y.) · 2012Article
- Relationships between the renal handling of DMPS and DMSA and the renal handling of mercury.Chemical research in toxicology · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mercuric ions accumulate preferentially in renal tubular epithelial cells and bond with intracellular thiols. Certain metal-complexing agents have been shown to promote extraction of mercuric ions via the multidrug resistance-associated protein 2 (MRP2). Following exposure to a non-toxic dose of inorganic mercury (Hg²+), in the absence of complexing agents, tubular cells are capable of exporting a small fraction of intracellular Hg²+ through one or more undetermined mechanisms. We hypothesize that MRP2 plays a role in this export. To test this hypothesis, Wistar (control) and TR(-) rats were injected intravenously with a non-nephrotoxic dose of HgCl₂ (0.5 μmol/kg) or CH₃HgCl (5 mg/kg), containing [²⁰³Hg], in the presence or absence of cysteine (Cys; 1.25 μmol/kg or 12.5mg/kg, respectively). Animals were sacrificed 24 h after exposure to mercury and the content of [²⁰³Hg] in blood, kidneys, liver, urine and feces was determined. In addition, uptake of Cys-S-conjugates of Hg²+ and methylmercury (CH₃Hg+) was measured in inside-out membrane vesicles prepared from either control Sf9 cells or Sf9 cells transfected with human MRP2. The amount of mercury in the total renal mass and liver was significantly greater in TR⁻ rats than in controls. In contrast, the amount of mercury in urine and feces was significantly lower in TR⁻ rats than in controls. Data from membrane vesicles indicate that Cys-S-conjugates of Hg²+ and CH₃Hg+ are transportable substrates of MRP2. Collectively, these data indicate that MRP2 plays a role in the physiological handling and elimination of mercuric ions from the kidney.
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Registered trials
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