ArticleBrain research2011
Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.
Article in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology.Molecular psychiatry · 2021Article
- Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.Journal of affective disorders · 2018Article
- Making Sense of: Sensitization in Schizophrenia.The international journal of neuropsychopharmacology · 2017Review
- Predator odor-evoked BOLD activation in the awake rat: modulation by oxytocin and V₁a vasopressin receptor antagonists.Brain research · 2013Article
- Brain processing of biologically relevant odors in the awake rat, as revealed by manganese-enhanced MRI.PloS one · 2012Article
- A bold view of the lactating brain: functional magnetic resonance imaging studies of suckling in awake dams.Journal of neuroendocrinology · 2011Review
- Technical and conceptual considerations for performing and interpreting functional MRI studies in awake rats.Frontiers in psychiatry · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Amphetamine, which is known to cause sensitization, potentiates the hormonal and neurobiological signatures of stress and may also increase sensitivity to stress-inducing stimuli in limbic areas. Trimethylthiazoline (5μL TMT) is a chemical constituent of fox feces that evokes innate fear and activates the neuronal and hormonal signatures of stress in rats. We used blood oxygen level dependent (BOLD) MRI to test whether amphetamine sensitization (1mg/kg, i.p. ×3days) in female rats has a lasting effect on the neural response to a stress-evoking stimulus, the scent of a predator, during the postpartum period. The subiculum and dopamine-enriched midbrain VTA/SN of amphetamine-sensitized but not control mothers showed a greater BOLD signal response to predator odor than a control putrid scent. The greater responsiveness of these two brain regions following stimulant sensitization might impact neural processing in response to stressors in the maternal brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.