ArticleCardiovascular diabetology2010
Insulin resistance and circadian rhythm of cardiac autonomic modulation.
Article in Cardiovascular diabetology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment.Frontiers in pharmacology · 2024Article
- Correlation of Circadian Rhythms of Heart Rate Variability Indices with Stress, Mood, and Sleep Status in Female Medical Workers with Night Shifts.Nature and science of sleep · 2022Article
- Insulin resistance and reduced cardiac autonomic function in older adults: the Atherosclerosis Risk in Communities study.BMC cardiovascular disorders · 2020Article
- Enhancing the Robustness of Smartphone Photoplethysmography: A Signal Quality Index Approach.Sensors (Basel, Switzerland) · 2020Article
- Time-restricted feeding for prevention and treatment of cardiometabolic disorders.The Journal of physiology · 2017Review
- Heart rate variability in normal-weight patients with polycystic ovary syndrome.Anatolian journal of cardiology · 2017Article
- The circadian pattern of cardiac autonomic modulation and obesity in adolescents.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2014Article
- Childhood obesity and autonomic dysfunction: risk for cardiac morbidity and mortality.Current treatment options in cardiovascular medicine · 2014Article
- Hypoglycemic effects and mechanisms of electroacupuncture on insulin resistance.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Effects of induced hyperinsulinaemia with and without hyperglycaemia on measures of cardiac vagal control.Diabetologia · 2013Article
- Ambulatory ECG-based T-wave alternans and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus.Cardiovascular diabetology · 2012Article
- Relationship of autonomic imbalance and circadian disruption with obesity and type 2 diabetes in resistant hypertensive patients.Cardiovascular diabetology · 2011Article
- Association of glycemic variability and the presence and severity of coronary artery disease in patients with type 2 diabetes.Cardiovascular diabetology · 2011Article
- Heart rate variability in restless legs syndrome and periodic limb movements of Sleep.Sleep science (Sao Paulo, Brazil)Article
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8 authors.
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Abstract
backgroundInsulin resistance (IR) has been associated with cardiovascular diseases (CVD). Heart rate variability (HRV), an index of cardiac autonomic modulation (CAM), is also associated with CVD mortality and CVD morbidity. Currently, there are limited data about the impairment of IR on the circadian pattern of CAM. Therefore, we conducted this investigation to exam the association between IR and the circadian oscillations of CAM in a community-dwelling middle-aged sample.
methodHomeostasis models of IR (HOMA-IR), insulin, and glucose were used to assess IR. CAM was measured by HRV analysis from a 24-hour electrocardiogram. Two stage modeling was used in the analysis. In stage one, for each individual we fit a cosine periodic model based on the 48 segments of HRV data. We obtained three individual-level cosine parameters that quantity the circadian pattern: mean (M), measures the overall average of a HRV index; amplitude (Â), measures the amplitude of the oscillation of a HRV index; and acrophase time (θ), measures the timing of the highest oscillation. At the second stage, we used a random-effects-meta-analysis to summarize the effects of IR variables on the three circadian parameters of HRV indices obtained in stage one of the analysis.
resultsIn persons without type diabetes, the multivariate adjusted β (SE) of log HOMA-IR and M variable for HRV were -0.251 (0.093), -0.245 (0.078), -0.19 (0.06), -4.89 (1.76), -3.35 (1.31), and 2.14 (0.995), for log HF, log LF, log VLF, SDNN, RMSSD and HR, respectively (all P < 0.05). None of the IR variables were significantly associated with  or θ of the HRV indices. However, in eight type 2 diabetics, the magnitude of effect due to higher HOMA-IR on M, Â, and θ are much larger.
conclusionElevated IR, among non-diabetics significantly impairs the overall mean levels of CAM. However, the  or θ of CAM were not significantly affected by IR, suggesting that the circadian mechanisms of CAM are not impaired. However, among persons with type 2 diabetes, a group clinically has more severe form of IR, the adverse effects of increased IR on all three HRV circadian parameters are much larger.
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