Evidence map›Paper›PMID 21134227›Full record

ReviewPeriodontology 20002011

Microbial shift and periodontitis.

Alex B Berezow, Richard P Darveau

4 registry-linked trialsAbstract readReview
In one paragraph

Review in Periodontology 2000, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 164 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06819761 nacompletednot on this mapstarted 2025, after this paper: background citation

A Short, Open, Phase 0 Study to Demonstrate the Viability of the Lozenge Dosage Form to Deliver SALI-10 Oral Probiotics

TypeinterventionalSponsorOstia SciencesRan2025 to 2025Enrolled8ConditionsDelivery Systems, Oral HealthArmsSalivarius SALI-10
NCT06871540 nacompletednot on this mapstarted 2023, after this paper: background citation

Evaluation Of The Effect Of Streptococcus Salivarius K12 Probiotic In The Treatment Of Periodontitis: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorAYŞENUR ŞAHİNRan2023 to 2024Enrolled30ConditionsPeriodontitis Stage III, ProbioticArmsProbiotic Agent, Non-Surgical Intervention
NCT07256743 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy SALI-10 Oral Probiotics in Experimental Gingivitis

TypeinterventionalSponsorOstia SciencesRan2025 to 2026Enrolled60ConditionsGingivitisArms6B SALI-10
NCT07508839 narecruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorOstia SciencesRan2026 to 2027Enrolled60ConditionsGingivitis, HalitosisArms3B SALI-10 Lozenge, Placebo
3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Three-dimensional analysis of initial biofilm formation on polytetrafluoroethylene in the oral cavity.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2013
    Trial
  10. Review
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  14. Compatibility of toothpastes with probiotics for periodontal health: anFrontiers in cellular and infection microbiology · 2026
    Article
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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alex B Berezow
Richard P Darveau

Funding

Oral Commensal Bacterial Modulation of the Periodontal Innate Host ResponseR01DE018274 · NIDCR · UNIVERSITY OF WASHINGTON · PI DARVEAU, RICHARD PETERS · 2007 to 2010
$1.2M
NIDCR NIH HHS R01 DE018274
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BiofilmsAntibiosisAnti-Infective AgentsAnti-Inflammatory AgentsBacteria, AnaerobicChronic PeriodontitisDental PlaqueHumansImmunomodulationPhotochemotherapyProbioticsAnti-Infective AgentsAnti-Inflammatory Agents

Identifiers

PMID21134227
PMCPMC3058494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.