ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Bioactive peptides derived from vascular endothelial cell extracellular matrices promote microvascular morphogenesis and wound healing in vitro.
Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Identification and characterization of a Fibrillin-1 derived matrikine for cardiac regeneration and repair.Biomaterials · 2026Article
- Identification and characterization of a Fibrillin-1 derived matrikine for cardiac regeneration and repair.bioRxiv : the preprint server for biology · 2025Article
- The Use of Therapeutic Peptides in Combination with Full-Thickness Skin Columns to Improve Healing of Excisional Wounds.Bioengineering (Basel, Switzerland) · 2025Article
- AMPEC4:Molecules (Basel, Switzerland) · 2025Article
- Curcumin Promotes Diabetic Foot Ulcer Wound Healing by Inhibiting miR-152-3p and Activating the FBN1/TGF-β Pathway.Molecular biotechnology · 2024Article
- Optimization of Hydrolysis Conditions, Isolation, and Identification of Biologically Active Peptides Derived fromAntioxidants (Basel, Switzerland) · 2024Article
- Jellyfishes-Significant Marine Resources with Potential in the Wound-Healing Process: A Review.Marine drugs · 2023Review
- Biological aspects in controlling angiogenesis: current progress.Cellular and molecular life sciences : CMLS · 2022Review
- Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine.Advances in wound care · 2022Review
- Bioactive peptides laden nano and micro-sized particles enriched ECM inspired dressing for skin regeneration in diabetic wounds.Materials today. Bio · 2022Article
- Enzyme-Digested Peptides Derived fromMarine drugs · 2021Article
- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins.Advances in experimental medicine and biology · 2021Article
- Identification ofFrontiers in cellular and infection microbiology · 2020Article
- The Roles of Tenascins in Cardiovascular, Inflammatory, and Heritable Connective Tissue Diseases.Frontiers in immunology · 2020Review
- The Bactericidal Activity of Temporin Analogues Against Methicillin ResistantInternational journal of molecular sciences · 2019Article
- A High-Throughput Workflow to Study Remodeling of Extracellular Matrix-Based Microtissues.Tissue engineering. Part C, Methods · 2019Article
- Multiple Roles of Tenascins in Homeostasis and Pathophysiology of Aorta.Annals of vascular diseases · 2018Article
- Towards an experimental classification system for membrane active peptides.Scientific reports · 2018Article
- Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries.Molecules (Basel, Switzerland) · 2017Review
- Static mechanical strain induces capillary endothelial cell cycle re-entry and sprouting.Physical biology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Studies in our laboratory indicate that collagenase from Clostridium histolyticum promotes endothelial cell and keratinocyte responses to injury in vitro and wound healing in vivo. We postulate that matrix degradation by Clostridial collagenase creates bioactive fragments that can stimulate cellular responses to injury and angiogenesis. To test this hypothesis, we performed limited digestion of defined capillary-endothelial-derived extracellular matrices using purified human or bacterial collagenases. Immunoprecipitation with antibodies recognizing collagens I, II, III, IV, and V, followed by mass spectrometry reveals the presence of unique fragments in bacterial, but not human-enzyme-digested matrix. Results show that there are several bioactive peptides liberated from Clostridial collagenase-treated matrices, which facilitate endothelial responses to injury, and accelerate microvascular remodeling in vitro. Fragments of collagen IV, fibrillin-1, tenascin X, and a novel peptide created by combining specific amino acids contained within fibrillin 1 and tenascin X each have profound proangiogenic properties. The peptides used at 10-100 nM increase rates of microvascular endothelial cell proliferation by up to 47% and in vitro angiogenesis by 200% when compared with serum-stimulated controls. Current studies are aimed at revealing the molecular mechanisms regulating peptide-induced wound healing while extending these in vitro observations using animal modeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.