ReviewCritical reviews in eukaryotic gene expression2010
Architectural genetic and epigenetic control of regulatory networks: compartmentalizing machinery for transcription and chromatin remodeling in nuclear microenvironments.
Review in Critical reviews in eukaryotic gene expression, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Enhancer of zeste homolog 2 (The Journal of biological chemistry · 2018Article
- Histone H4 Methyltransferase Suv420h2 Maintains Fidelity of Osteoblast Differentiation.Journal of cellular biochemistry · 2017Article
- KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.Cell death & disease · 2016Article
- Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells.Journal of cellular physiology · 2016Article
- Review
- Article
- A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts.Journal of cellular physiology · 2014Article
- KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells.International journal of oral science · 2013Article
- Enhanced CRAd activity using enhancer motifs driven by a nucleosome positioning sequence.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Functional impairment of bone formation in the pathogenesis of osteoporosis: the bone marrow regenerative competence.Current osteoporosis reports · 2013Review
- Chromatin remodeling in cancer: a gateway to regulate gene transcription.Molecular oncology · 2012Review
- Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.Cell stem cell · 2012Article
- A RUNX2-HDAC1 co-repressor complex regulates rRNA gene expression by modulating UBF acetylation.Journal of cell science · 2012Article
- Twenty-four chromosome FISH in human IVF embryos reveals patterns of post-zygotic chromosome segregation and nuclear organisation.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- Nuclear organisation of sperm remains remarkably unaffected in the presence of defective spermatogenesis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Novel insights on the positive correlation between sense and antisense pairs on gene expression.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The regulatory machinery that governs genetic and epigenetic control of gene expression for biological processes and cancer is organized in nuclear microenvironments. Strategic placement of transcription factors at target gene promoters in punctate microenvironments of interphase nuclei supports scaffolding of co- regulatory proteins and the convergence as well as integration of regulatory networks. The organization and localization of regulatory complexes within the nucleus can provide signatures that are linked to regulatory activity. Retention of transcription factors at gene loci in mitotic chromosomes contributes to epigenetic control of cell fate and lineage commitment, as well as to persistence of transformed and tumor phenotypes. Mechanistic understanding of the architectural assembly of regulatory machinery can serve as a basis for treating cancer with high specificity and minimal off-target effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.