ReviewCritical reviews in eukaryotic gene expression2010
Recent advances in the use of serological bone formation markers to monitor callus development and fracture healing.
Review in Critical reviews in eukaryotic gene expression, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- LINC00662 regulates osteogenic differentiation of BMSCs and inhibits fracture healing via miR-330-3p/PTEN axis.BMC musculoskeletal disorders · 2025Article
- Diagnostic and Prognostic Value of Indicators of Bone Metabolism Markers in Patients Following Mandibulectomy and Free Fibula Flap Reconstruction with Endosteal Implants.Journal of maxillofacial and oral surgery · 2024Article
- Association between Bone Turnover Markers and Fracture Healing in Long Bone Non-Union: A Systematic Review.Journal of clinical medicine · 2024Review
- Effects of Erythropoietin-Promoted Fracture Healing on Bone Turnover Markers in Cats.Journal of functional biomaterials · 2024Article
- The Signalling Effects of Photobiomodulation on Osteoblast Proliferation, Maturation and Differentiation: A Review.Stem cell reviews and reports · 2021Review
- Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Article
- Can bone marrow aspirate improve mandibular fracture repair in camels (Journal of veterinary science · 2020Article
- Prognostic potential of markers of bone turnover in delayed-healing tibial diaphyseal fractures.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2019Observational
- Clinical Utility of Biochemical Marker of Bone Turnover: Fracture Risk Prediction and Bone Healing.Journal of bone metabolism · 2018Review
- Teriparatide as a nonoperative treatment for tibial and femoral fracture nonunion: A case report.Medicine · 2017Article
- Changes of Bone Turnover Markers in Long Bone Nonunions Treated with a Regenerative Approach.Stem cells international · 2017Article
- Mice with a heterozygous Lrp6 deletion have impaired fracture healing.Bone research · 2016Article
- Mice lacking pten in osteoblasts have improved intramembranous and late endochondral fracture healing.PloS one · 2013Article
- Application of Platelet-rich Plasma and Tricalcium Phosphate in the Treatment of Comminuted Fractures in Animals.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The failure of an osseous fracture to heal, or the development of a nonunion, is common; however, current diagnostic measures lack the capability of early and reliable detection of such events. Analyses of radiographic imaging and clinical examination, in combination, remain the gold standard for diagnosis; however, these methods are not reliable for early detection. Delayed diagnosis of a nonunion is costly from both the patient and treatment standpoints. In response, repeated efforts have been made to identify bone metabolic markers as diagnostic or prognostic tools for monitoring bone healing. Thus far, the evidence regarding a correlation between the kinetics of most bone metabolic markers and nonunion is very limited. With the aim of classifying the role of biological pathways of bone metabolism and of understanding bone conditions in the development of osteoporosis, advances have been made in our knowledge of the molecular basis of bone remodeling, fracture healing, and its failure. Procollagen type I amino-terminal propeptide has been shown to be a reliable bone formation marker in osteoporosis therapy and its kinetics during fracture healing has been recently described. In this article, we suggest that procollagen type I amino-terminal propeptide presents a good opportunity for early detection of nonunion. We also review the role and potential of serum PINP, as well as other markers, as indications of fracture healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.