ArticleLeukemia & lymphoma2011
Association of HLA-DQB1 alleles with risk of follicular lymphoma.
Article in Leukemia & lymphoma, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population.Leukemia & lymphoma · 2019Article
- Genetic Variants Associated with FDNY WTC-Related Sarcoidosis.International journal of environmental research and public health · 2019Article
- Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression.Genes and immunity · 2014Article
- Transformation in follicular lymphoma: biology, prognosis, and therapeutic options.Current oncology reports · 2012Review
- Multi-locus HLA class I and II allele and haplotype associations with follicular lymphoma.Tissue antigens · 2012Article
- Multiplexed, ligation-dependent probe amplification for rapid and inexpensive HLA-DQB1 allelotyping.Tissue antigens · 2011Article
- SNP rs6457327 in the HLA region on chromosome 6p is predictive of the transformation of follicular lymphoma.Blood · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In a recent genome-wide association study of follicular lymphoma (FL), we identified novel risk alleles on chromosome 6p21.33 that appeared to be part of an extended haplotype including HLA-DRB1*0101, DQA1*0101, and DQB1*0501. To follow up on these findings, we obtained 2-4 digit HLA-DQB1 allelotypes on a subset of 265 cases of FL and 757 controls using a novel assay that applies multiplexed ligation-dependent probe amplification (MLPA). We confirmed a positive association between FL and the HLA-DQB1*05 allele group (OR = 1.70, 95% CI 1.28-2.27; adjusted p-value = 0.013) and also identified an allele group inversely associated with FL risk, HLA-DQB1*06 (OR = 0.51, 95% CI 0.38-0.69; adjusted p-value = 4.46 × 10(-5)). Although these findings require verification, the role of HLA class II proteins in B-cell survival and proliferation makes this a biologically plausible association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.