ArticleJournal of proteome research2011
Networked-based characterization of extracellular matrix proteins from adult mouse pulmonary and aortic valves.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- ADAMTS7, a target in atherosclerosis, cooperates with its homolog ADAMTS12 to protect against myxomatous valve degeneration.Journal of molecular and cellular cardiology plus · 2025Article
- The Spatial Extracellular Proteomic Tumor Microenvironment Distinguishes Molecular Subtypes of Hepatocellular Carcinoma.Journal of proteome research · 2024Article
- Review
- Perspectives on pediatric congenital aortic valve stenosis: Extracellular matrix proteins, post translational modifications, and proteomic strategies.Frontiers in cardiovascular medicine · 2022Review
- Absence of the MFG-E8 gene prevents hypoxia-induced pulmonary hypertension in mice.Journal of cellular physiology · 2021Article
- Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling.Developmental biology · 2019Article
- Proteomic Alterations Associated with Biomechanical Dysfunction are Early Processes in the Emilin1 Deficient Mouse Model of Aortic Valve Disease.Annals of biomedical engineering · 2017Article
- Elucidating the Molecular Composition of Cartilage by Proteomics.Journal of proteome research · 2016Article
- Proteomic analysis of naturally-sourced biological scaffolds.Biomaterials · 2016Article
- Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis.Journal of cardiovascular development and disease · 2014Article
- Advances in the treatment of aortic valve disease: is it time for companion diagnostics?Current opinion in pediatrics · 2014Review
- TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease.Disease models & mechanisms · 2014Article
- Global analysis reveals the complexity of the human glomerular extracellular matrix.Journal of the American Society of Nephrology : JASN · 2014Article
- Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Milk fat globule epidermal growth factor VIII signaling in arterial wall remodeling.Current vascular pharmacology · 2013Review
- Defining the extracellular matrix using proteomics.International journal of experimental pathology · 2013Review
- Systems proteomics for translational network medicine.Circulation. Cardiovascular genetics · 2012Article
- Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.Developmental biology · 2011Article
- Characterizing nanoscale topography of the aortic heart valve basement membrane for tissue engineering heart valve scaffold design.Tissue engineering · 2006Article
- Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
A precise mixture of extracellular matrix (ECM) secreted by valvular cells forms a scaffold that lends the heart valve the exact mechanical and tensile strength needed for accurate hemodynamic performance. ECM proteins are a key component of valvular endothelial cell (VEC)-valvular interstitial cell (VIC) communication essential for maintenance of the valve structure. This study reports the healthy adult pulmonary and aortic valve proteomes characterized by LC-MS/MS, resulting in 2710 proteins expressed by 1513 genes, including over 300 abundant ECM proteins. Surprisingly, this study defines a distinct proteome for each semilunar valve. Protein-protein networking (PPN) was used as a tool to direct selection of proteomic candidates for biological investigation. Local PPN for nidogen 1 (Nid1), biglycan (Bgn), elastin microfibril interface-located protein 1 (Emilin-1), and milk fat globule-EGF factor 8 protein (Mfge8) were enriched with proteins essential to valve function and produced biological functions highly relevant to valve biology. Immunofluorescent investigations demonstrated that these proteins are functionally distributed within the pulmonary and aortic valve structure, indicative of important contribution to valve function. This study yields new insight into protein expression contributing to valvular maintenance and health and provides a platform for unbiased assessment of protein alterations during disease processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.