ArticleThe European journal of health economics : HEPAC : health economics in prevention and care2012
Comparing the sensitivity of EQ-5D, SF-6D and 15D utilities to the specific effect of diabetic complications.
Article in The European journal of health economics : HEPAC : health economics in prevention and care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Psychometric properties of the EQ-5D-5L: a systematic review of the literature.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Pooled it
- Measuring the quality of life of patients with diabetic retinopathy in northern India: a comparison of generic and vision specific instruments.Health and quality of life outcomes · 2025Article
- Determinants of health-related quality of life of patients with type 2 diabetes and multimorbidity: a cross-sectional study.Hormones (Athens, Greece) · 2024Article
- Utilities for Complications Associated with Type 2 Diabetes: A Review of the Literature.Advances in therapy · 2024Review
- Comparison of three health-related quality of life instruments in relation to visual acuity: EQ-5D, 15D, and EUROHIS-QOL8.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- A Comparison of EQ-5D-3L, EQ-5D-5L, and SF-6D Utilities of Patients with Musculoskeletal Disorders of Different Severity: A Health-Related Quality of Life Approach.Journal of clinical medicine · 2022Article
- New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review.Frontiers in endocrinology · 2022Review
- Evaluating the Impact of Therapy on Quality of Life in Type 2 Diabetes: A Literature Review of Utilities Associated with Treatment-Related Attributes.Patient related outcome measures · 2022Review
- Economic evaluation of using polygenic risk score to guide risk screening and interventions for the prevention of type 2 diabetes in individuals with high overall baseline risk.Frontiers in genetics · 2022Article
- Type 2 Diabetes-Related Health Economic Impact Associated with Increased Whole Grains Consumption among Adults in Finland.Nutrients · 2021Article
- Pharmacy-based screening to detect persons at elevated risk of type 2 diabetes: a cost-utility analysis.BMC health services research · 2021Article
- Article
- Health-related quality of life and health utilities in insulin-treated type 2 diabetes: the impact of related comorbidities/complications.The European journal of health economics : HEPAC : health economics in prevention and care · 2020Article
- Health-related quality of life in patients with esophageal cancer or precancerous lesions assessed by EQ-5D: A multicenter cross-sectional study.Thoracic cancer · 2020Article
- Association between TUG and Anthropometric Values, Vibration Perception Threshold, FHSQ and 15-D in Type 2 Diabetes Mellitus Patients.International journal of environmental research and public health · 2020Article
- Health related quality of life and satisfaction with care of stroke patients in Budapest: A substudy of the EuroHOPE project.PloS one · 2020Article
- Diabetic retinopathy and health-related quality of life among Chinese with known type 2 diabetes mellitus.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Comparison of health-related quality of Life (HRQOL) among patients with pre-diabetes, diabetes and normal glucose tolerance, using the 15D-HRQOL questionnaire in Greece: the DEPLAN study.BMC endocrine disorders · 2018Article
- Comparative performance of the EQ-5D-5L and SF-6D index scores in adults with type 2 diabetes.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Is quality of life different between diabetic and non-diabetic people? The importance of cardiovascular risks.PloS one · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDiabetes patients suffer from comorbid conditions and disease-related complications. Combined with demographic, clinical and treatment satisfaction variables, they have a confounding effect on health-related quality of life (HRQoL). This study compared the sensitivity of EQ-5D, SF-6D and 15D utilities to the specific effect of diabetes complications.
methodsUtilities were compared in 319 type II diabetics with and without comorbidities and complications. Based on subsample size and confirmed diagnoses, coronary heart disease (CHD) and diabetic retinopathy (DR) were two complications chosen for further analysis. Significant EQ-5D, SF-6D and 15D predictors were identified with OLS regression and subsequently controlled for with ANCOVA.
resultsThe presence of CHD resulted in utility decrements (P < 0.001) for all instruments, whereas DR only decreased 15D utilities (P < 0.05). Gender, age, treatment satisfaction, arthropathy and diabetic foot were significant predictors throughout, whereas BMI, neuropathy and CHD for at least two utilities. After controlling for these confounding variables, 15D still discriminated between diabetics with and without CHD (P < 0.01) and DR (P < 0.05), with seven and five dimensions affected, respectively.
conclusionsAfter removing the effect of background variables, 15D utilities remain sensitive to CHD and DR. The obvious explanation is its richer descriptive system, which provides increased discriminative ability compared to EQ-5D and SF-6D, and this might be evidence for preferring the 15D in economic evaluations of interventions for diabetics. However, the need remains for further testing in other diabetes complications and more diverse patient samples.
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