ArticleJournal of neuro-oncology2011
Longitudinal MRI evidence for decreased survival among periventricular glioblastoma.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis.Journal of neuro-oncology · 2017Pooled it
- Extent of resection and survival in IDH-wildtype glioblastoma: interaction with MGMT status and chemoradiation.Journal of neuro-oncology · 2026Article
- Accelerating MRI With Longitudinally-Informed Latent Posterior Sampling.Magnetic resonance in medicine · 2026Article
- IGFBP-2 and IGF-II: Key Components of the Neural Stem Cell Niche? Implications for Glioblastoma Pathogenesis.International journal of molecular sciences · 2025Review
- Ependymal invasion in High-Grade Glioma. Impact on surgical, functional outcomes, and survival rates. Experience in a Latin-American center.Neurosurgical review · 2025Article
- Functional and structural reorganization in brain tumors: a machine learning approach using desynchronized functional oscillations.Communications biology · 2024Article
- Review
- Influence of glioblastoma contact with the subventricular zone on survival and recurrence patterns.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Combination of the Distance From Tumor Edge to Subventricular Zone and IDH Mutation Predicts Prognosis of Patients With Glioma.Frontiers in oncology · 2021Article
- Influence of wide opening of the lateral ventricle on survival for supratentorial glioblastoma patients with radiotherapy and concomitant temozolomide-based chemotherapy.Neurosurgical review · 2020Article
- The influence of subventricular zone involvement in extent of resection and tumor growth pattern of glioblastoma.Innovative surgical sciences · 2020Article
- Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state.Journal of neuro-oncology · 2020Article
- MR image phenotypes may add prognostic value to clinical features in IDH wild-type lower-grade gliomas.European radiology · 2020Article
- The added prognostic value of radiological phenotype combined with clinical features and molecular subtype in anaplastic gliomas.Journal of neuro-oncology · 2019Article
- Location-Dependent Patient Outcome and Recurrence Patterns in IDH1-Wildtype Glioblastoma.Cancers · 2019Article
- Adverse prognosis of glioblastoma contacting the subventricular zone: Biological correlates.PloS one · 2019Article
- The role of interleukin-6-STAT3 signalling in glioblastoma.Oncology letters · 2018Review
- Role of STAT3 in Genesis and Progression of Human Malignant Gliomas.Molecular neurobiology · 2017Review
- Decreased survival in glioblastomas is specific to contact with the ventricular-subventricular zone, not subgranular zone or corpus callosum.Journal of neuro-oncology · 2017Article
- Ependymal enhancement on magnetic resonance imaging for the identification of high-grade gliomas.Surgical neurology international · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the prognosis of patients with glioblastoma (GBM) remains poor despite recent therapeutic advances, variable survival times suggest wide variation in tumor biology and an opportunity for stratified intervention. We used volumetric analysis and morphometrics to measure the spatial relationship between subventricular zone (SVZ) proximity and survival in a cohort of 39 newly diagnosed GBM patients. We collected T2-weighted and gadolinium-enhanced T1-weighted magnetic resonance images (MRI) at pre-operative, post-operative, pre-radiation therapy, and post-radiation therapy time points, measured tumor volumes and distances to the SVZ, and collected clinical data. Univariate and multivariate Cox regression showed that tumors involving the SVZ and tumor growth rate during radiation therapy were independent predictors of shorter progression-free and overall survival. These results suggest that GBMs in close proximity to the ependymal surface of the ventricles convey a worse prognosis-an observation that may be useful for stratifying treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.