ReviewJournal of muscle research and cell motility2010
Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing.
Review in Journal of muscle research and cell motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A novel kinetic model to demonstrate the independent effects of ATP and ADP/Pi concentrations on sarcomere function.PLoS computational biology · 2024Article
- A century of exercise physiology: key concepts in muscle energetics.European journal of applied physiology · 2023Review
- The effects of inorganic phosphate on muscle force development and energetics: challenges in modelling related to experimental uncertainties.Journal of muscle research and cell motility · 2021Article
- Special Issue: The Actin-Myosin Interaction in Muscle: Background and Overview.International journal of molecular sciences · 2019Review
- Myosin Cross-Bridge Behaviour in Contracting Muscle-The TInternational journal of molecular sciences · 2019Article
- Comparing models with one versus multiple myosin-binding sites per actin target zone: The power of simplicity.The Journal of general physiology · 2019Article
- Nonlinear Actomyosin Elasticity in Muscle?Biophysical journal · 2019Article
- Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle?International journal of molecular sciences · 2018Review
- Temperature Effects on Force and Actin⁻Myosin Interaction in Muscle: A Look Back on Some Experimental Findings.International journal of molecular sciences · 2018Review
- Temperature effect on the chemomechanical regulation of substeps within the power stroke of a single Myosin II.Scientific reports · 2016Article
- Contribution of elastic tissues to the mechanics and energetics of muscle function during movement.The Journal of experimental biology · 2016Review
- The endothermic ATP hydrolysis and crossbridge attachment steps drive the increase of force with temperature in isometric and shortening muscle.The Journal of physiology · 2015Article
- Poorly understood aspects of striated muscle contraction.BioMed research international · 2015Review
- The non-linear elasticity of the muscle sarcomere and the compliance of myosin motors.The Journal of physiology · 2014Article
- Flexibility within the heads of muscle myosin-2 molecules.Journal of molecular biology · 2014Article
- Stiffness, working stroke, and force of single-myosin molecules in skeletal muscle: elucidation of these mechanical properties via nonlinear elasticity evaluation.Cellular and molecular life sciences : CMLS · 2013Review
- A cross-bridge cycle with two tension-generating steps simulates skeletal muscle mechanics.Biophysical journal · 2013Article
- Mechanism of force enhancement during stretching of skeletal muscle fibres investigated by high time-resolved stiffness measurements.Journal of muscle research and cell motility · 2013Article
- Mechanism of force enhancement during and after lengthening of active muscle: a temperature dependence study.Journal of muscle research and cell motility · 2012Article
- Mechanics of myosin function in white muscle fibres of the dogfish, Scyliorhinus canicula.The Journal of physiology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The stiffness of myosin heads attached to actin is a crucial parameter in determining the kinetics and mechanics of the crossbridge cycle. It has been claimed that the stiffness of myosin heads in the anterior tibialis muscle of the common frog (Rana temporaria) is as high as 3.3 pN/nm, substantially higher than its value in rabbit muscle (~1.7 pN/nm). However, the crossbridge stiffness measurement has a large error since the contribution of crossbridges to half-sarcomere compliance is obtained by subtracting from the half-sarcomere compliance the contributions of the thick and thin filaments, each with a substantial error. Calculation of its value for isometric contraction also depends on the fraction of heads that are attached, for which there is no consensus. Surprisingly, the stiffness of the myosin head from the edible frog, Rana esculenta, determined in the same manner, is only 60% of that in Rana temporaria. In our view it is unlikely that the value of such a crucial parameter could differ so substantially between two frog species. Since the means of the myosin head stiffness in these two species are not significantly different, we suggest that the best estimate of the stiffness of the myosin heads for frog muscle is the average of these data, a value similar to that for rabbit muscle. This would allow both frog and rabbit muscles to operate the same low-cooperativity mechanism for the crossbridge cycle with only one or two tension-generating steps. We review evidence that much of the compliance of the myosin head is located in the pliant region where the lever arm emerges from the converter and propose that tension generation ("tensing") caused by the rotation and movement of the converter is a separate event from the passive swinging of the lever arm in its working stroke in which the strain energy stored in the pliant region is used to do work.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.