ArticleExpert review of endocrinology & metabolism2010
A New Hypothesis for Insulin Resistance in Hypertension Due to Receptor Cleavage.
Article in Expert review of endocrinology & metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- New insights on the cardiovascular effects of IGF-1.Frontiers in endocrinology · 2023Pooled it
- Pancreatic Microcirculation Profiles in the Progression of Hypertension in Spontaneously Hypertensive Rats.American journal of hypertension · 2021Article
- Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis.Physiological research · 2020Article
- Pancreatic source of protease activity in the spontaneously hypertensive rat and its reduction during temporary food restriction.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Glucose homeostasis dependency on acini-islet-acinar (AIA) axis communication: a new possible pathophysiological hypothesis regarding diabetes mellitus.Nutrition & diabetes · 2018Review
- IGF-1 receptor cleavage in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Mechanisms of I/R-Induced Endothelium-Dependent Vasodilator Dysfunction.Advances in pharmacology (San Diego, Calif.) · 2018Review
- The autodigestion hypothesis: Proteolytic receptor cleavage in rheological and cardiovascular cell dysfunction1.Biorheology · 2016Article
- Proteolytic receptor cleavage in the pathogenesis of blood rheology and co-morbidities in metabolic syndrome. Early forms of autodigestion.Biorheology · 2015Review
- Hyperinsulinemia is Associated with Increased Soluble Insulin Receptors Release from Hepatocytes.Frontiers in endocrinology · 2014Article
- Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock.Shock (Augusta, Ga.) · 2014Article
- Proteolytic Activity Attenuates the Response of Endothelial Cells to Fluid Shear Stress.Cellular and molecular bioengineering · 2012Article
- An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavage.Current hypertension reports · 2012Review
- Proteolytic Cleavage of the Red Blood Cell Glycocalyx in a Genetic Form of Hypertension.Cellular and molecular bioengineering · 2011Article
- Mast Cell Proteases and Inflammation.Drug discovery today. Disease models · 2011Article
- Receptor cleavage reduces the fluid shear response in neutrophils of the spontaneously hypertensive rat.American journal of physiology. Cell physiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOne of the most important unresolved issues in diabetes is the mechanism for the attenuated response to insulin, i.e. insulin resistance. AIMS AND
methodsWe hypothesize that the mechanism for the insulin resistance is due to uncontrolled protease activity in the plasma, on endothelial cells and in the tissue parenchyma. To examine this hypothesis we use of microzymographic techniques in the microcirculation, plasma zymography, and receptor labeling techniques with antibodies against an extracellular domain of the insulin receptor α.
resultsThe spontaneously hypertensive rat has an enhanced proteolytic activity and significant cleavage of the receptor with attenuated glucose transport. We present evidence for insulin receptor cleavage in a high fat diet and a transgenic model of diabetes.
conclusionThese results suggest that cleavage of the extracellular domain of the insulin receptor, a situation that interferes with the ability for insulin to bind and provide an intracellular signal for glucose transport, may be involved in insulin resistance.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.