ArticleThe EMBO journal2011
Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 70 citations in OpenAlex.
- Traversing the effects of ploidy changes in different Eragrostis curvula genotypes through high-throughput RNA sequencing.The plant genome · 2026Article
- SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots.Journal of plant research · 2025Article
- Supplementary UV-A and UV-B radiation differentially regulate morphology in Ocimum basilicum.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Polyploidization of Hepatocytes: Insights into the Pathogenesis of Liver Diseases.Biomolecules & therapeutics · 2022Review
- Ultraviolet-B Radiation Represses Primary Root Elongation by Inhibiting Cell Proliferation in the Meristematic Zone of Arabidopsis Seedlings.Frontiers in plant science · 2022Article
- Impact of polyploidy on plant tolerance to abiotic and biotic stresses.Frontiers in plant science · 2022Review
- Downsizing in plants-UV light induces pronounced morphological changes in the absence of stress.Plant physiology · 2021Article
- The Controversial Role of Polyploidy in Hepatocellular Carcinoma.OncoTargets and therapy · 2021Review
- Endopolyploidy is a common response to UV-B stress in natural plant populations, but its magnitude may be affected by chromosome type.Annals of botany · 2020Article
- Polyploidy in liver development, homeostasis and disease.Nature reviews. Gastroenterology & hepatology · 2020Review
- Dynamic gene expression changes in response to micronutrient, macronutrient, and multiple stress exposures in soybean.Functional & integrative genomics · 2020Article
- Size matters: three methods for estimating nuclear size in mycorrhizal roots of Medicago truncatula by image analysis.BMC plant biology · 2019Article
- Article
- Role of a cotton endoreduplication-related gene, GaTOP6B, in response to drought stress.Planta · 2019Article
- The Plant DNA Damage Response: Signaling Pathways Leading to Growth Inhibition and Putative Role in Response to Stress Conditions.Frontiers in plant science · 2019Review
- Endoreplication: The Good, the Bad, and the Ugly.Trends in cell biology · 2018Review
- DNA double-strand breaks promote endoreduplication in radish cotyledon.Plant cell reports · 2018Article
- HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.Frontiers in plant science · 2017Article
- UVR2 ensures transgenerational genome stability under simulated natural UV-B in Arabidopsis thaliana.Nature communications · 2016Article
- DNA damage and repair in plants - from models to crops.Frontiers in plant science · 2015Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of their sessile life style, plants have evolved the ability to adjust to environmentally harsh conditions. An important aspect of stress adaptation involves the reprogramming of the cell cycle to ensure optimal growth. The atypical E2F transcription factor DP-E2F-like 1 (E2Fe/DEL1) had been found previously to be an important regulator of the endocycle onset. Here, a novel role for E2Fe/DEL1 was identified as a transcriptional repressor of the type-II cyclobutane pyrimidine dimer-photolyase DNA repair gene PHR1. Upon ultraviolet-B (UV-B) treatment, plants knocked out for E2Fe/DEL1 had improved DNA repair abilities when compared with control plants, whereas those overexpressing it performed less well. Better DNA repair allowed E2Fe/DEL1 knockout plants to resume endoreduplication faster than control plants, contributing in this manner to UV-B radiation resistance by compensating the stress-induced reduction in cell number by ploidy-dependent cell growth. As E2Fe/DEL1 levels decreased upon UV-B treatment, we hypothesize that the coordinated transcriptional induction of PHR1 with the endoreduplication onset contributes to the adaptation of plants exposed to UV-B stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.