ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2011
Comprehensive diagnostic battery for evaluating sensorineural hearing loss in children.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 5 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Outcomes of Cochlear Implantation in Patients with Jervell and Lange-Nielsen Syndrome: A Systematic Review and Narrative Synthesis.The journal of international advanced otology · 2020Pooled it
- Assessment of the Clinical Benefit of Imaging in Children With Unilateral Sensorineural Hearing Loss: A Systematic Review and Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2019Pooled it
- Diagnostic yield of MRI for pediatric hearing loss: a systematic review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2015Pooled it
- Diagnostic yield of computed tomography scan for pediatric hearing loss: a systematic review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Pooled it
- Task force Guideline of Brazilian Society of Otology ‒ hearing loss in children - Part I ‒ Evaluation.Brazilian journal of otorhinolaryngologyGuideline
- A treatment-focused approach to medical investigations for hearing loss in infants.Journal of the Royal Society of New Zealand · 2025Review
- Article
- Full etiologic spectrum of pediatric severe to profound hearing loss of consecutive 119 cases.Scientific reports · 2022Article
- Comprehensive medical evaluation of pediatric bilateral sensorineural hearing loss.Laryngoscope investigative otolaryngology · 2021Review
- Electrophysiology and genetic testing in the precision medicine of congenital deafness: A review.Journal of otology · 2021Review
- A proposal for comprehensive newborn hearing screening to improve identification of deaf and hard-of-hearing children.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- Diagnosis and Management of Congenital Sensorineural Hearing Loss.Current treatment options in pediatrics · 2016Article
- Bilirubin-Induced Audiologic Injury in Preterm Infants.Clinics in perinatology · 2016Review
- Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis: A Report of the Association for Molecular Pathology.The Journal of molecular diagnostics : JMD · 2016Review
- A Mayan founder mutation is a common cause of deafness in Guatemala.Clinical genetics · 2016Article
- Sensorineural Hearing Loss: A Changing Paradigm for Its Evaluation.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2015Article
- DNA sequence analysis and genotype-phenotype assessment in 71 patients with syndromic hearing loss or auditory neuropathy.BMJ open · 2015Article
- Audiologic impairment associated with bilirubin-induced neurologic damage.Seminars in fetal & neonatal medicine · 2015Review
- Cognitive outcomes and familial stress after cochlear implantation in deaf children with and without developmental delays.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2012Article
- Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography.Optics express · 2011Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSelection of diagnostic tests for children with sensorineural hearing loss (SNHL) is influenced by clinical suspicion. Testing results reported in the literature are similarly biased. We evaluate the usefulness of a comprehensive diagnostic battery for each child. STUDY
designRetrospective review.
settingTertiary care university hospital. PATIENTS: A total of 270 children referred for severe to profound SNHL between January 2002 and June 2009.
interventionsResults of the following were reviewed: magnetic resonance imaging, computed tomography, renal ultrasound, electrocardiography, fluorescent treponemal antibody absorption test, connexin 26 sequencing, genetic consultation, and ophthalmologic consultation.
main outcome measureDiagnostic yield of each test was determined.
resultsEach diagnostic test or consultation was completed by at least 95% of patients for whom it was ordered. Magnetic resonance imaging revealed abnormalities explaining SNHL in 24% of patients. Computed tomography showed inner ear anomalies in 18% of patients. Biallelic connexin 26 mutations were found in 15%. Renal ultrasound found anomalies in 4% of patients. Electrocardiography found 1% of patients with prolonged QT intervals. Fluorescent treponemal antibody absorption test result was positive in 0.5%. Genetic consultation found a genetic cause for hearing loss in 25%. Ophthalmologic consultation found abnormalities associated with hearing loss in 8%.
conclusionDiagnostic radiologic imaging is the highest yielding test for evaluating children with SNHL. Connexin 26 sequencing identifies a nearly nonoverlapping subset of children compared with imaging. Specialty consultations, particularly from a clinical geneticist, can improve diagnostic yield. Other tests, although of lower diagnostic yield for SNHL, can identify important diseases that significantly affect patient health.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.