ArticleAmerican journal of respiratory and critical care medicine2011
Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Proteomic profiling of bronchoalveolar lavage following human segmental endotoxin challenge-a potential exacerbation model.Scientific reports · 2026Article
- Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults.Immunity, inflammation and disease · 2022Observational
- Early Immunomodulatory Effects of Different Natural Surfactant Preparations in Preterms With Respiratory Distress.Frontiers in pediatrics · 2022Article
- Lower Oligomeric Form of Surfactant Protein D in Murine Acute Lung Injury Induces M1 Subtype Macrophages Through Calreticulin/p38 MAPK Signaling Pathway.Frontiers in immunology · 2021Article
- Surfactant protein-D modulation of pulmonary macrophage phenotype is controlled byAmerican journal of physiology. Lung cellular and molecular physiology · 2019Article
- Ozone Inhalation Attenuated the Effects of Budesonide onFrontiers in immunology · 2019Article
- Oxidative damage of SP-D abolishes control of eosinophil extracellular DNA trap formation.Journal of leukocyte biology · 2018Article
- Surfactant Protein D in Respiratory and Non-Respiratory Diseases.Frontiers in medicine · 2018Review
- Role of NOS2 in pulmonary injury and repair in response to bleomycin.Free radical biology & medicine · 2016Article
- Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2015Article
- Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?American journal of respiratory cell and molecular biology · 2014Review
- Role of serum and induced sputum surfactant protein D in predicting the response to treatment in chronic obstructive pulmonary disease.Experimental and therapeutic medicine · 2014Article
- Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics.BMC immunology · 2014Article
- Impact of surfactant protein D, interleukin-5, and eosinophilia on Cryptococcosis.Infection and immunity · 2014Article
- SNObase, a database for S-nitrosation modification.Protein & cell · 2012Article
- Update in asthma 2011.American journal of respiratory and critical care medicine · 2012Review
- S-nitrosylation of surfactant protein D as a modulator of pulmonary inflammation.Biochimica et biophysica acta · 2012Review
- IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M.The Journal of allergy and clinical immunology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
rationaleSurfactant protein D (SP-D), a 43-kD collectin, is synthesized and secreted by airway epithelia as a dodecamer formed by assembly of four trimeric subunits. We have previously shown that the quaternary structure of SP-D can be altered during inflammatory lung injury through its modification by S-nitrosylation, which in turn alters its functional behavior producing a proinflammatory response in effector cells.
objectivesWe hypothesized that alterations in structure and function of SP-D may occur in humans with acute allergic inflammation.
methodsBronchoalveolar lavage (BAL) fluid was collected from 15 nonsmoking patients with mild intermittent allergic asthma before and 24 hours after segmental provocation with saline, allergen, LPS, and mixtures of allergen and LPS. Structural modifications of SP-D were analyzed by native and sodium dodecyl sulfate gel electrophoresis. MEASUREMENTS AND MAIN
resultsThe multimeric structure of native SP-D was found to be disrupted after provocation with allergen or a mixture of allergen and LPS. Interestingly, under reducing conditions, sodium dodecyl sulfate-polyacrylamide gel electrophoresis demonstrated that 7 of 15 patients with asthma developed an abnormal cross-linked SP-D band after segmental challenge with either allergen or a mixture of allergen with LPS but not LPS alone. Importantly, patients with asthma with cross-linked SP-D demonstrated significantly higher levels of BAL eosinophils, nitrogen oxides, IL-4, IL-5, IL-13, and S-nitrosothiol-SP-D compared with patients without cross-linked SP-D.
conclusionsWe conclude that segmental allergen challenge results in changes of SP-D multimeric structure and that these modifications are associated with an altered local inflammatory response in the distal airways.
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