ArticleAmerican journal of physiology. Lung cellular and molecular physiology2011
Chronic intermittent hypoxia induces lung growth in adult mice.
Article in American journal of physiology. Lung cellular and molecular physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026Review
- Platelets in angiogenesis and pulmonary progenitor cell homing under chronic intermittent hypoxia.Scientific reports · 2025Article
- Single-cell landscape of mouse lungs exposed to intermittent hypoxia.Respiratory research · 2025Article
- Sucrose- and fat-related metabolic states influence the adaptation of the pulmonary lipid metabolism to hypoxia.Cell and tissue research · 2025Article
- Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats.Sleep & breathing = Schlaf & Atmung · 2021Article
- Article
- The Effects of Chronic Intermittent Hypoxia in Bleomycin-Induced Lung Injury on Pulmonary Fibrosis via Regulating the NF-κB/Nrf2 Signaling Pathway.Tuberculosis and respiratory diseases · 2020Article
- Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposure.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Attenuation of intermittent hypoxia-induced apoptosis and fibrosis in pulmonary tissues via suppression of ER stress activation.BMC pulmonary medicine · 2020Article
- Acclimatization of low altitude-bred deer mice ( Peromyscus maniculatus) to high altitude.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Article
- Relationship between surfactant proteins B and C and obstructive sleep apnea: is serum SP-B concentration a potential biomarker of obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2016Article
- Increased Cardiac Output and Preserved Gas Exchange Despite Decreased Alveolar Surface Area in Rats Exposed to Neonatal Hyperoxia and Adult Hypoxia.American journal of respiratory cell and molecular biology · 2015Article
- What do changes in concentrations of serum surfactant proteins A and D in OSA mean?Sleep & breathing = Schlaf & Atmung · 2015Article
- Alveolar-capillary adaptation to chronic hypoxia in the fatty lung.Acta physiologica (Oxford, England) · 2015Article
- Inflammation in sleep apnea: an update.Reviews in endocrine & metabolic disorders · 2015Review
- Simulating obstructive sleep apnea patients' oxygenation characteristics into a mouse model of cyclical intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Persistent structural adaptation in the lungs of guinea pigs raised at high altitude.Respiratory physiology & neurobiology · 2015Article
- Involvement of calcium-sensing receptors in hypoxia-induced vascular remodeling and pulmonary hypertension by promoting phenotypic modulation of small pulmonary arteries.Molecular and cellular biochemistry · 2014Article
- Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) increases cardiovascular morbidity and mortality, which have been attributed to intermittent hypoxia (IH). The effects of IH on lung structure and function are unknown. We used a mouse model of chronic IH, which mimics the O(2) profile in patients with OSA. We exposed adult C57BL/6J mice to 3 mo of IH with a fraction of inspired oxygen (F(I)(O(2))) nadir of 5% 60 times/h during the 12-h light phase. Control mice were exposed to room air. Lung volumes were measured by quasistatic pressure-volume (PV) curves under anesthesia and by water displacement postmortem. Lungs were processed for morphometry, and the mean airspace chord length (Lm) and alveolar surface area were determined. Lung tissue was stained for markers of proliferation (proliferating cell nuclear antigen), apoptosis (terminal deoxynucleotidyl transferase dUTP nick-end labeling), and type II alveolar epithelial cells (surfactant protein C). Gene microarrays were performed, and results were validated by real-time PCR. IH increased lung volumes by both PV curves (air vs. IH, 1.16 vs. 1.44 ml, P < 0.0001) and water displacement (P < 0.01) without changes in Lm, suggesting that IH increased the alveolar surface area. IH induced a 60% increase in cellular proliferation, but the number of proliferating type II alveolocytes tripled. There was no increase in apoptosis. IH upregulated pathways of cellular movement and cellular growth and development, including key developmental genes vascular endothelial growth factor A and platelet-derived growth factor B. We conclude that IH increases alveolar surface area by stimulating lung growth in adult mice.
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