Trial reportJapanese journal of clinical oncology2011
Randomized controlled trial on effectiveness of ultrasonography screening for breast cancer in women aged 40-49 (J-START): research design.
Trial report in Japanese journal of clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.The Cochrane database of systematic reviews · 2023Pooled it
- Mammography in combination with breast ultrasonography versus mammography for breast cancer screening in women at average risk.The Cochrane database of systematic reviews · 2013Pooled it
- Trial
- Impact of breast size and composition on the accuracy of mammography and ultrasonography in breast cancer screening.Breast cancer (Tokyo, Japan) · 2025Article
- The effects of breast density on the benefits of mammograms with adjunctive ultrasonography in breast screening.Breast cancer (Tokyo, Japan) · 2024Article
- Quantifying the potential benefits of early detection for pancreatic cancer through a counterfactual simulation modeling analysis.Scientific reports · 2023Article
- Evaluation of Adjunctive Ultrasonography for Breast Cancer Detection Among Women Aged 40-49 Years With Varying Breast Density Undergoing Screening Mammography: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2021Article
- Overall assessment system of combined mammography and ultrasound for breast cancer screening in Japan.Breast cancer (Tokyo, Japan) · 2021Article
- Can mechanical imaging increase the specificity of mammography screening?European radiology · 2017Article
- A novel two-dimensional quantitative shear wave elastography for differentiating malignant from benign breast lesions.International journal of clinical and experimental medicine · 2015Article
- Diagnostic accuracy of FDG-PET cancer screening in asymptomatic individuals: use of record linkage from the Osaka Cancer Registry.International journal of clinical oncology · 2014Article
- Retrospective analysis of mammographic findings for Japanese women: a potential predictor for breast malignancies.Cancer science · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cancer screening, it is essential to undertake effective screening with appropriate methodology, which should be supported by evidence of a reduced mortality rate. At present, mammography is the only method for breast cancer screening with such evidence. However, mammography does not achieve sufficient accuracy in breasts with high density at ages below 50. Although ultrasonography achieves better accuracy in Breast Cancer detection even in dense breasts, the effectiveness has not been verified. We have planned a randomized controlled trial to assess the effectiveness of ultrasonography in women aged 40-49, with a design to study 50,000 women with mammography and ultrasonography (intervention group), and 50,000 controls with mammography only (control group). The participants are scheduled to take second round screening with the same modality 2 years on. The primary endpoints are sensitivity and specificity, and the secondary endpoint is the rate of advanced breast cancers.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.