ArticleNucleic acids research2011
Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription.
Article in Nucleic acids research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Integration of CTCF loops, methylome, and transcriptome in differentiating LUHMES as a model for imprinting dynamics of the 15q11-q13 locus in human neurons.Human molecular genetics · 2024Article
- Inter-subspecies mouse F1 hybrid embryonic stem cell lines newly established for studies of allelic imbalance in gene expression.Experimental animals · 2024Article
- Specific ZNF274 binding interference at SNORD116 activates the maternal transcripts in Prader-Willi syndrome neurons.Human molecular genetics · 2020Article
- Prader-Willi syndrome: reflections on seminal studies and future therapies.Open biology · 2020Review
- A human somatic cell culture system for modelling gene silencing by transcriptional interference.Heliyon · 2020Article
- Mechanisms of Tactile Sensory Phenotypes in Autism: Current Understanding and Future Directions for Research.Current psychiatry reports · 2019Review
- Markers associated with neuron-specific Ube3a imprinting during neuronal differentiation of mouse embryonic stem cells.Cytotechnology · 2018Article
- Enhanced Nociception in Angelman Syndrome Model Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Expression and imprinting of DIO3 and DIO3OS genes in Holstein cattle.Journal of genetics · 2017Article
- Genomic imprinting does not reduce the dosage of UBE3A in neurons.Epigenetics & chromatin · 2017Article
- Comparison of two types of non-adherent plate for neuronal differentiation of mouse embryonic stem cells.Cytotechnology · 2016Article
- Angelman syndrome - insights into a rare neurogenetic disorder.Nature reviews. Neurology · 2016Review
- Allelic specificity of Ube3a expression in the mouse brain during postnatal development.The Journal of comparative neurology · 2014Article
- Long non-coding RNAs and complex human diseases.International journal of molecular sciences · 2013Review
- Epigenetic layers and players underlying neurodevelopment.Trends in neurosciences · 2013Review
- Research progress in allele-specific expression and its regulatory mechanisms.Journal of applied genetics · 2013Review
- Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model.PLoS genetics · 2013Article
- Review
- Ube3a-ATS is an atypical RNA polymerase II transcript that represses the paternal expression of Ube3a.Human molecular genetics · 2012Article
- Imprinting and expression of Dio3os mirrors Dio3 in rat.Frontiers in genetics · 2012Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We investigated the allele- and strand-specific transcriptional landscape of a megabase-wide genomic region of mouse Ube3a (ubiquitin protein ligase E3A) by means of a highly parallel SNP genotyping platform. We have successfully identified maternal-specific expression of Ube3a and its antisense counterpart (Ube3a-ATS) in brain, but not in liver. Because of the use of inter-subspecies hybrid mice, this megabase-wide analysis provided high-resolution picture of the transcriptional patterns of this region. First, we showed that brain-specific maternal expression of Ube3a is restricted to the second half part of the locus, but is absent from the first half part. Balance of allelic expression is altered in the middle of the locus. Second, we showed that expression of the brain-specific Ube3a-ATS appeared to be terminated in the region upstream to the Ube3a transcription start site. The present study highlights the importance of locus-wide competition between sense and antisense transcripts.
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