ArticleBurns : journal of the International Society for Burn Injuries2011
An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolates.
Article in Burns : journal of the International Society for Burn Injuries, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 90 citations in OpenAlex.
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- Efficacy of a novel thermo-reversible wound gel against antibiotic tolerant biofilm.Frontiers in antibiotics · 2026Article
- Antimicrobial Efficacy of Impregnated Human Acellular Dermal Substitutes in Burn Wound Models.Antibiotics (Basel, Switzerland) · 2025Article
- Transcriptomic and functional profiling ofFrontiers in microbiology · 2025Article
- Wound Gel Formulations Containing Poloxamer 407 and Polyhexanide HaveMicroorganisms · 2024Article
- Design and Evaluation of Microemulsion-Based Drug Delivery Systems for Biofilm-Based Infection in Burns.AAPS PharmSciTech · 2024Article
- Herbal Polyphenols as Selenium Reducers in the Green Synthesis of Selenium Nanoparticles: Antibacterial and Antioxidant Capabilities of the Obtained SeNPs.Molecules (Basel, Switzerland) · 2024Article
- Intra-abdominal packing does not increase infection risk or mandate longer presumptive antibiotic therapy.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2023Article
- Nitrate respiration occurs throughout the depth of mucoid and non-mucoid Pseudomonas aeruginosa submerged agar colony biofilms including the oxic zone.Scientific reports · 2022Article
- Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using anRegenerative biomaterials · 2021Article
- Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems.Drug delivery and translational research · 2021Review
- Distribution and Antibiotic Resistance Patterns of Pathogenic Bacteria in Patients With Chronic Cutaneous Wounds in China.Frontiers in medicine · 2021Article
- Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: A proof of concept study.International journal of pharmaceutics: X · 2020Article
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- Thriving Under Stress:Frontiers in cellular and infection microbiology · 2020Article
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- Evaluation of Biofilm Formation and Frequency of Multidrug-resistant and Extended Drug-resistant Strain inAdvanced biomedical research · 2018Article
- Nanomedicine and advanced technologies for burns: Preventing infection and facilitating wound healing.Advanced drug delivery reviews · 2018Review
- Microbial Biofilms and Chronic Wounds.Microorganisms · 2017Review
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8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTopical treatment of burn wounds is essential as reduced blood supply in the burned tissues restricts the effect of systemic antibiotics. On the burn surface, microorganisms exist within a complex structure termed a biofilm, which enhances bacterial resistance to antimicrobial agents significantly. Since bacteria differ in their ability to develop biofilms, the susceptibility of these biofilms to topically applied antibiotics varies, making it essential to identify which topical antibiotics efficiently disrupt or prevent biofilms produced by these pathogens. Yet, a simple in vitro assay to compare the susceptibility of biofilms produced by burn wound isolates to different topical antibiotics has not been reported.
methodsBiofilms were developed by inoculating cellulose disks on agar plates with burn wound isolates and incubating for 24h. The biofilms were then covered for 24h with untreated gauze or gauze coated with antibiotic ointment and remaining microorganisms were quantified and visualized microscopically.
resultsMupirocin and triple antibiotic ointments significantly reduced biofilms produced by the Staphylococcus aureus and Pseudomonas aeruginosa burn wound isolates tested, as did gentamicin ointment, with the exception of one P. aeruginosa clinical isolate.
conclusionsThe described assay is a practical and reproducible approach to identify topical antibiotics most effective in eliminating biofilms produced by burn wound isolates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.