ArticleAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2010
Development of atopy by severe paramyxoviral infection in a mouse model.
Article in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03039101 (Double Blind Study of Leukotriene Antagonism in the Nasal Recruitment of CD49d Expressing Neutrophils in Atopic Subjects), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Double Blind Study of Leukotriene Antagonism in the Nasal Recruitment of CD49d Expressing Neutrophils in Atopic Subjects
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Are we there yet? understanding interactions between respiratory viral infections, atopy, and the microbiome.Frontiers in allergy · 2026Review
- Neuregulin-1 prevents death from a normally lethal respiratory viral infection.PLoS pathogens · 2025Article
- Moderate-to-severe lower respiratory tract infection in early life is associated with increased risk of polysensitization and atopic dermatitis: Findings from the CHILD Study.The journal of allergy and clinical immunology. Global · 2022Article
- Atopic Neutrophils Prevent Postviral Airway Disease.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Article
- Asthma and viral infections: An intricate relationship.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- Post-viral atopic airway disease: pathogenesis and potential avenues for intervention.Expert review of clinical immunology · 2019Review
- Respiratory viral infections and atopic development: From possible mechanisms to advances in treatment.European journal of immunology · 2018Review
- POL7085 or anti-CCL28 treatment inhibits development of post-paramyxoviral airway disease.Immunity, inflammation and disease · 2017Article
- Rhinoviruses and Their Receptors: Implications for Allergic Disease.Current allergy and asthma reports · 2016Review
- Structure-function analysis of CCL28 in the development of post-viral asthma.The Journal of biological chemistry · 2015Article
- Editorial: RSV, dendritic cells, and allergens--a bad combination.Journal of leukocyte biology · 2013Article
- The role of early life viral bronchiolitis in the inception of asthma.Current opinion in allergy and clinical immunology · 2013Review
- Role of viruses in the development of atopic disease in pediatric patients.Current allergy and asthma reports · 2012Review
- Expression of high-affinity IgE receptor on human peripheral blood dendritic cells in children.PloS one · 2012Article
- Dendritic cells, viruses, and the development of atopic disease.Journal of allergy · 2012Article
- Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice.PloS one · 2012Article
- Characterization of intestinal dendritic cells in murine norovirus infection.The open immunology journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAtopic diseases have been increasing in prevalence, yet the initial inciting events that lead to atopy are not understood. Paramyxoviral infections have been suggested to play a role; however, much of these data are correlative.
objectiveTo determine whether exposure to a nonviral antigen during a paramyxoviral infection is sufficient to drive IgE production against the bystander antigen and whether clinical disease against this antigen would result.
methodsWild-type C57BL6 mice or mice deficient in FcεRIα (FcεRIα(-/-)) or IgE (IgE(-/-)) were inoculated with Sendai virus (SeV) or UV-inactivated SeV (UV-SeV) and subsequently exposed to ovalbumin (OVA) intranasally. Mice were further challenged 3 times with intranasal OVA on days 20 to 22 after inoculation with SeV, and airway hyperreactivity and mucous cell metaplasia were determined.
resultsExposure to OVA during SeV infection led to significant OVA specific IgE production (median, 548 vs 0 ng/mL; P = .03; SeV vs UV-SeV). This induction of OVA specific IgE production depended on FcεRI because FcεRIα(-/-) mice produced significantly less IgE (112 ng/mL; P = .03; vs wild-type mice). Furthermore, in wild-type mice OVA exposure and challenge significantly enhanced SeV-induced airway hyperreactivity and mucous cell metaplasia, but this failed to occur in either FcεRIα(-/-) or IgE(-/-) mice.
conclusionA single exposure to a bystander allergen during a paramyxoviral infection is sufficient to drive allergen specific IgE production in a partial FcεRI-dependent mechanism. These data begin to provide mechanistic insight into how viral infections might drive development of atopic disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.