ReviewBrain research2011
Divergent mechanisms for trophic actions of estrogens in the brain and peripheral tissues.
Review in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Gonad pathology, sex hormone modulation and vitellogenin expression inFrontiers in toxicology · 2024Article
- Tributyltin Exposure Is Associated With Recognition Memory Impairments, Alterations in Estrogen Receptor α Protein Levels, and Oxidative Stress in the Brain of Female Mice.Frontiers in toxicology · 2021Article
- Differential activation of Gsk-3β in the cortex and the hippocampus induces cognitive and behavioural impairments in middle-aged ovariectomized rat.Comprehensive psychoneuroendocrinology · 2020Article
- Neuroimmunomodulation by estrogen in health and disease.AIMS neuroscience · 2020Review
- Non-Feminizing Estrogens Do Not Exhibit Antidepressant-like Activity.Journal of pharmaceutics and drug research · 2016Article
- Progestogens' effects and mechanisms for object recognition memory across the lifespan.Behavioural brain research · 2015Review
- Effects of sex, menstrual cycle phase, and endogenous hormones on cognition in schizophrenia.Schizophrenia research · 2015Article
- Non-feminizing estrogens: a novel neuroprotective therapy.Molecular and cellular endocrinology · 2014Review
- Effects of hormone therapy on cognition and mood.Fertility and sterility · 2014Review
- Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia.Frontiers in integrative neuroscience · 2013Article
- Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.Molecular endocrinology (Baltimore, Md.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
17β-estradiol (E(2)) can enhance reproductive, cognitive, and affective functions; however, the mechanisms by which E(2) has these effects need to be better understood. Pleiotrophic effects of E(2) can occur via traditional and novel actions at various forms of estrogen receptors (ERs). In the central nervous system, trophic effects of E(2) may be related to beneficial effects of hormone replacement therapy (HRT). However, in peripheral reproductive tissues, E(2)'s capacity to evoke growth can increase risk of cancers. This review focuses on investigations aimed at elucidating divergent mechanisms of steroids to promote trophic effects in the brain, independent of effects on peripheral reproductive tissues. First, actions of estrogens via ERα or ERβ for peripheral growth (carcinogen-induced tumors, uterine growth) and hippocampus-dependent behaviors (affect, cognition) are described. Second, factors that influence these effects of estrogens are described (e.g. experience, timing/critical windows, non-ER mechanisms). Third, effects of estrogens at ERβ related to actions of progestogens, such as 5α-pregnan-3α-ol-20-one (3α,5α-THP) are described. In summary, effects of E(2) may occur via multiple mechanisms, which may underlie favorable effects in the brain with minimal peripheral trophic effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.