ArticlePsychiatry research2011
Heart rate variability during motor and cognitive tasks in females with major depressive disorder.
Article in Psychiatry research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder.Molecular psychiatry · 2025Pooled it
- Atypical reactivity of heart rate variability to stress and depression across development: Systematic review of the literature and directions for future research.Clinical psychology review · 2016Pooled it
- The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Pooled it
- Brain-heart interactions in late-onset major depressive disorder revealed by multimodal HRV-driven fMRI.Communications biology · 2026Article
- Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Economic Choice and Heart Rate Fractal Scaling Indicate That Cognitive Effort Is Reduced by Depression and Boosted by Sad Mood.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- The autonomic brain: Multi-dimensional generative hierarchical modelling of the autonomic connectome.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Applying Heart Rate Variability to Monitor Health and Performance in Tactical Personnel: A Narrative Review.International journal of environmental research and public health · 2021Review
- Childhood anxiety sensitivity, fear downregulation, and anxious behaviors: Vagal suppression as a moderator of risk.Emotion (Washington, D.C.) · 2021Article
- Emotion context insensitivity in depression: Toward an integrated and contextualized approach.Psychophysiology · 2021Review
- Heart Rate Variability Moderates the Association Between Beliefs About Worry and Generalized Anxiety Disorder Symptoms.Frontiers in neuroscience · 2020Article
- Autonomic Nervous System Is Related to Inhibitory and Control Function Through Functional Inter-Region Connectivities of OFC in Major Depression.Neuropsychiatric disease and treatment · 2020Article
- Entropy analysis of heart rate variability and its application to recognize major depressive disorder: A pilot study.Technology and health care : official journal of the European Society for Engineering and Medicine · 2019Article
- Gender- and Age-Specific Differences in Resting-State Functional Connectivity of the Central Autonomic Network in Adulthood.Frontiers in human neuroscience · 2019Article
- Increases in orbitofrontal cortex thickness following antidepressant treatment are associated with changes in resting state autonomic function in adolescents with major depression - Preliminary findings from a pilot study.Psychiatry research. Neuroimaging · 2018Article
- Inflexibility as a Vulnerability to Depression: A Systematic Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2017Article
- Article
- Higher Heart-Rate Variability Is Associated with Ventromedial Prefrontal Cortex Activity and Increased Resistance to Temptation in Dietary Self-Control Challenges.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges.Biological psychology · 2015Article
- Adolescent RSA responses during an anger discussion task: Relations to emotion regulation and adjustment.Emotion (Washington, D.C.) · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Research indicates that major depressive disorder (MDD) is associated with alterations in autonomic control, particularly cardiac control as measured by heart rate variability (HRV). In this preliminary study, we investigated the neural correlates of autonomic control by measuring both HRV and associated brain activity during the performance of mildly stressful tasks. Medically healthy female subjects with MDD (N=10) and healthy controls (N=7) underwent H(2)(15)O-positron emission tomography (PET) and electrocardiographic ECG recording while performing a handgrip motor task and an n-back task. Indices of HRV were calculated and correlated with regional cerebral blood flow (rCBF). Differences in the rCBF and HRV correlations between depressed and healthy subjects were evident in both the medial and lateral orbital cortices. In addition, these areas appeared to be involved in different facets of autonomic control with regard to sympathetic or parasympathetic dominance of cardiac control. These results are consistent with the known roles of networks within the orbital cortex in both autonomic control and the pathophysiology of MDD.
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Registered trials
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