Evidence map›Paper›PMID 21129791›Full record

ReviewTrends in neurosciences2011

Development, specification, and diversity of callosal projection neurons.

Ryann M Fame, Jessica L MacDonald, Jeffrey D Macklis

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 2 pooled it
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 2 syntheses or guidelines pooled it, 380 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  14. Review
  15. Interneuron Diversity: How Form Becomes Function.Cold Spring Harbor perspectives in biology · 2025
    Review
  16. Article
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  19. Autism spectrum disorder-like behaviors induced by hyper-glutamatergic NMDA receptor signaling through hypo-serotonergic 5-HTNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  20. Article

166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryann M FameMGH-HMS Center for Nervous System Repair, Department of Neurosurgery, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA.
Jessica L MacDonald
Jeffrey D Macklis
Harvard University · US

Funding

Molecular Controls over Neurogenesis, Subtype Development, and Diversity of Cortical Output Projection NeuronsR01NS045523 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2002 to 2020
$5.4M
Neocortical Precursor Transplant for Circuitry RepairR37NS041590 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2010
$2.9M
Cortico-Spinal Repopulation from Precursors for RepairR01NS049553 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2004 to 2007
$1.6M
NEOCORTICAL PRECURSOR TRANSPLANTS FOR CIRCUITRY REPAIRR01NS041590 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MACKLIS, JEFFREY D · 2000 to 2003
$1.5M
NINDS NIH HHS NS41590NINDS NIH HHS NS45523NINDS NIH HHS NS49553NINDS NIH HHS R01 NS041590NINDS NIH HHS R01 NS045523NINDS NIH HHS R01 NS049553NINDS NIH HHS R37 NS041590
6 · The paper itself

Abstract

Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative connectivity, and have been implicated in cognitive syndromes of high-level associative dysfunction, such as autism spectrum disorders. CPN evolved relatively recently compared to other cortical neuron populations, and have undergone disproportionately large expansion from mouse to human. While much is known about the anatomical trajectory of developing CPN axons, and progress has been made in identifying cellular and molecular controls over midline crossing, only recently have molecular-genetic controls been identified that specify CPN populations, and help define CPN subpopulations. In this review, we discuss the development, diversity and evolution of CPN.

Indexed as

AnimalsCerebral CortexCorpus CallosumHumansNeurons

Identifiers

PMID21129791
PMCPMC3053014
OpenAlexW2031030159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.