ArticleNeurobiology of learning and memory2011
Ontogeny and neural substrates of the context preexposure facilitation effect.
Article in Neurobiology of learning and memory, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 69 citations in OpenAlex.
- Diversity of clustered protocadherin-α genes in neuronal identity and its role in short-term specific associative memory formation.Scientific reports · 2025Article
- Postnatal development of the relaxin-3 innervation of the rat medial septum.Frontiers in neuroscience · 2023Article
- Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.Biology open · 2022Article
- A method for the selective depletion of microglia in the dorsal hippocampus in the juvenile rat brain.Journal of neuroscience methods · 2022Article
- The influence of sex, genotype, and dose on serum and hippocampal cytokine levels in juvenile mice developmentally exposed to a human-relevant mixture of polychlorinated biphenyls.Current research in toxicology · 2020Article
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Cholinergic rescue of neurocognitive insult following third-trimester equivalent alcohol exposure in rats.Neurobiology of learning and memory · 2019Article
- Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.The American journal of psychiatry · 2019Review
- Differential involvement of amygdalar NMDA receptors across variants of contextual fear conditioning in adolescent rats.Behavioural brain research · 2019Article
- Impairment of the context preexposure facilitation effect in juvenile rats by neonatal alcohol exposure is associated with decreased Egr-1 mRNA expression in the prefrontal cortex.Behavioral neuroscience · 2018Article
- Contextual fear retrieval-induced Fos expression across early development in the rat: An analysis using established nervous system nomenclature ontology.Neurobiology of learning and memory · 2018Article
- Neurocognitive Development of Motivated Behavior: Dynamic Changes across Childhood and Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Mechanisms of critical period in the hippocampus underlie object location learning and memory in infant rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Age and experience dependent changes in Egr-1 expression during the ontogeny of the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Differential expression of the immediate early genes c-Fos, Arc, Egr-1, and Npas4 during long-term memory formation in the context preexposure facilitation effect (CPFE).Neurobiology of learning and memory · 2018Article
- Neonatal infection produces significant changes in immune function with no associated learning deficits in juvenile rats.Developmental neurobiology · 2017Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Differential involvement of the medial prefrontal cortex across variants of contextual fear conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Adolescent transitions in reflexive and non-reflexive behavior: Review of fear conditioning and impulse control in rodent models.Neuroscience and biobehavioral reviews · 2016Review
- Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults.Brain research · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Contextual fear conditioning emerges around post-natal day (PD) 23 in the rat. This is thought to reflect hippocampus-dependent conjunctive learning, which binds the individual features of the context into a unified representation (Rudy, 1993). However, context conditioning can also be supported by hippocampus-independent, feature-based simple associations (Rudy, 2009) and these may operate at PD 23-24 (Pugh & Rudy, 1996). To address this issue, we studied the ontogeny of a variant of contextual fear conditioning, termed the context-preexposure-facilitation-effect (CPFE), in which exposure to context and (immediate) foot shock occur on successive occasions. This variant requires conjunctive as opposed to feature-based simple associations (Rudy, 2009). We tested PD 17, 24, and 31 rats on the CPFE vs. conventional context conditioning (Exp. 1) and on the CPFE with stronger reinforcement (Exp. 2). The CPFE emerged on PD 24 regardless of reinforcer strength and in parallel with context conditioning. Infusions of the NMDA-receptor antagonist, MK-801, into the dorsal hippocampus just before pre-exposure on PD 24 eliminated the CPFE, whereas infusions occurring after pre-exposure had no effect (Exp. 3). These findings demonstrate a role of hippocampal NMDA receptors in the CPFE as early as PD 24 and implicate conjunctive learning mechanisms in the ontogeny of contextual fear conditioning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.