ArticleBiochimica et biophysica acta2011
The cell surface structure of tumor endothelial marker 8 (TEM8) is regulated by the actin cytoskeleton.
Article in Biochimica et biophysica acta, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder.Scientific reports · 2024Article
- Elevated expression ofFrontiers in molecular biosciences · 2024Article
- Review
- Evolving role of seneca valley virus and its biomarker TEM8/ANTXR1 in cancer therapeutics.Frontiers in molecular biosciences · 2022Review
- The Biological Role of the Collagen Alpha-3 (VI) Chain and Its Cleaved C5 Domain Fragment Endotrophin in Cancer.OncoTargets and therapy · 2020Review
- Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.American journal of translational research · 2020Article
- Article
- TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo.PloS one · 2019Article
- Converging physiological roles of the anthrax toxin receptors.F1000Research · 2019Review
- TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.Cell communication and signaling : CCS · 2018Article
- Article
- Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release.The Journal of clinical investigation · 2018Article
- Improved Protein Toxin Delivery Based on ATTEMPTS Systems.Current drug targets · 2018Review
- TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer.Cancer research · 2018Article
- Indirubin inhibits cell proliferation, migration, invasion and angiogenesis in tumor-derived endothelial cells.OncoTargets and therapy · 2018Article
- Fell-Muir Lecture: Regulatory mechanisms of skeletal and connective tissue development and homeostasis - lessons from studies of human disorders.International journal of experimental pathology · 2016Review
- Tumour endothelial marker-8 in wound healing and its impact on the proliferation and migration of keratinocytes.International journal of molecular medicine · 2016Article
- Biomarkers Discovery for Colorectal Cancer: A Review on Tumor Endothelial Markers as Perspective Candidates.Disease markers · 2016Review
- Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle.PloS one · 2016Article
- Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.Matrix biology : journal of the International Society for Matrix Biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Tumor endothelial marker 8 (TEM8) is an integrin-like cell surface protein upregulated on tumor blood vessels and a potential vascular target for cancer therapy. Here, we found that the ability of an anti-TEM8 antibody, clone SB5, to recognize the extracellular domain of TEM8 on the cell surface depends on other host-cell factors. By taking advantage of SB5's ability to distinguish different forms of cell surface TEM8, we identified alpha-smooth muscle actin and transgelin, an actin binding protein, as intracellular factors able to alter TEM8 cell surface structure. Overexpression of either of these proteins in cells converted TEM8 from an SB5-exposed to an SB5-masked form and protected cells from SB5-saporin immunotoxins. Because the predominant form of TEM8 on the cell surface is not recognized by SB5, we also developed a new monoclonal antibody, called AF334, which is able to recognize both the SB5-exposed and the SB5-masked forms of TEM8. AF334-saporin selectively killed TEM8-positive cells independent of TEM8 cell surface structure. These studies reveal that TEM8 exists in different forms at the cell surface, a structure dependent on interactions with components of the actin cytoskeleton, and should aid in the rational design of the most effective diagnostic and therapeutic anti-TEM8 monoclonal antibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.