Trial reportJournal of diabetes science and technology2010
Design and clinical pilot testing of the model-based dynamic insulin sensitivity and secretion test (DISST).
Trial report in Journal of diabetes science and technology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- Evaluation of pharmacokinetic model designs for subcutaneous infusion of insulin aspart.Journal of pharmacokinetics and pharmacodynamics · 2017Trial
- A novel hierarchal-based approach to measure insulin sensitivity and secretion in at-risk populations.Journal of diabetes science and technology · 2014Trial
- Determining Losses in Jet Injection Subcutaneous Insulin Delivery: A Model-Based Approach.Journal of diabetes science and technology · 2023Article
- The Effects of Additional Local-Mixing Compartments in the DISST Model-Based Assessment of Insulin Sensitivity.Journal of diabetes science and technology · 2022Article
- The Impact of Exogenous Insulin Input on Calculating Hepatic Clearance Parameters.Journal of diabetes science and technology · 2022Article
- Variability in Estimated Modelled Insulin Secretion.Journal of diabetes science and technology · 2022Article
- Estimating Increased EGP During Stress Response in Critically Ill Patients.Journal of diabetes science and technology · 2021Article
- Insulin sensitivity in critically ill patients: are women more insulin resistant?Annals of intensive care · 2021Article
- Levels and Diagnostic Value of Model-based Insulin Sensitivity in Sepsis: A Preliminary Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2018Article
- The Need to Calculate Target Glucose Levels When Measuring Changes in Insulin Sensitivity During Interventions for Individuals With Type 2 Diabetes.Journal of diabetes science and technology · 2018Article
- Untangling glycaemia and mortality in critical care.Critical care (London, England) · 2017Article
- The necessity of identifying the basal glucose set-point in the IVGTT for patients with Type 2 Diabetes.Biomedical engineering online · 2015Article
- Use of the DISST model to estimate the HOMA and Matsuda indexes using only a basal insulin assay.Journal of diabetes science and technology · 2014Article
- Iterative integral parameter identification of a respiratory mechanics model.Biomedical engineering online · 2012Article
- Characterisation of the iterative integral parameter identification method.Medical & biological engineering & computing · 2012Article
- A spectrum of dynamic insulin sensitivity test protocols.Journal of diabetes science and technology · 2011Article
- A graphical method for practical and informative identifiability analyses of physiological models: a case study of insulin kinetics and sensitivity.Biomedical engineering online · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin sensitivity and secretion test (DISST), a high-resolution, low-intensity test to diagnose insulin sensitivity (IS) and characterize pancreatic insulin secretion in response to a (small) glucose challenge. This pilot study examines the effect of glucose and insulin dose on the DISST, and tests its repeatability.
methodsDISST tests were performed on 16 subjects randomly allocated to low (5 g glucose, 0.5 U insulin), medium (10 g glucose, 1 U insulin) and high dose (20 g glucose, 2 U insulin) protocols. Two or three tests were performed on each subject a few days apart.
resultsAverage variability in IS between low and medium dose was 10.3% (p=.50) and between medium and high dose 6.0% (p=.87). Geometric mean variability between tests was 6.0% (multiplicative standard deviation (MSD) 4.9%). Geometric mean variability in first phase endogenous insulin response was 6.8% (MSD 2.2%). Results were most consistent in subjects with low IS.
conclusionsThese findings suggest that DISST may be an easily performed dynamic test to quantify IS with high resolution, especially among those with reduced IS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.