ArticleJournal of diabetes science and technology2010
Multinational study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results.
Article in Journal of diabetes science and technology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00977808 (Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes), which is not on this map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes(BPK004)
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Meta-analysis of overnight closed-loop randomized studies in children and adults with type 1 diabetes: the Cambridge cohort.Journal of diabetes science and technology · 2011Pooled it
- Trial
- Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide.Diabetes care · 2016Trial
- Multinight "bedside" closed-loop control for patients with type 1 diabetes.Diabetes technology & therapeutics · 2015Trial
- Trial
- Role of glucagon-like peptide-1 analogue versus amylin as an adjuvant therapy in type 1 diabetes in a closed loop setting with ePID algorithm.Journal of diabetes science and technology · 2014Trial
- Overnight glucose control with an automated, unified safety system in children and adolescents with type 1 diabetes at diabetes camp.Diabetes care · 2014Trial
- Safety of nighttime 2-hour suspension of Basal insulin in pump-treated type 1 diabetes even in the absence of low glucose.Diabetes care · 2014Trial
- Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial.Diabetes care · 2014Trial
- Trial
- Reduced hypoglycemia and increased time in target using closed-loop insulin delivery during nights with or without antecedent afternoon exercise in type 1 diabetes.Diabetes care · 2013Trial
- Model-based closed-loop glucose control in type 1 diabetes: the DiaCon experience.Journal of diabetes science and technology · 2013Trial
- Susceptibility of interstitial continuous glucose monitor performance to sleeping position.Journal of diabetes science and technology · 2013Trial
- Clinical evaluation of a personalized artificial pancreas.Diabetes care · 2013Trial
- Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2013Trial
- Effect of pramlintide on prandial glycemic excursions during closed-loop control in adolescents and young adults with type 1 diabetes.Diabetes care · 2012Trial
- Effect of insulin feedback on closed-loop glucose control: a crossover study.Journal of diabetes science and technology · 2012Trial
- Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes.Diabetes care · 2012Trial
- Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia.Diabetes · 2012Trial
- A stepwise approach toward closed-loop blood glucose control for intensive care unit patients: results from a feasibility study in type 1 diabetic subjects using vascular microdialysis with infrared spectrometry and a model predictive control algorithm.Journal of diabetes science and technology · 2011Trial
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundIn 2008-2009, the first multinational study was completed comparing closed-loop control (artificial pancreas) to state-of-the-art open-loop therapy in adults with type 1 diabetes mellitus (T1DM).
methodsThe design of the control algorithm was done entirely in silico, i.e., using computer simulation experiments with N=300 synthetic "subjects" with T1DM instead of traditional animal trials. The clinical experiments recruited 20 adults with T1DM at the Universities of Virginia (11); Padova, Italy (6); and Montpellier, France (3). Open-loop and closed-loop admission was scheduled 3-4 weeks apart, continued for 22 h (14.5 h of which were in closed loop), and used a continuous glucose monitor and an insulin pump. The only difference between the two sessions was that insulin dosing was performed by the patient under a physician's supervision during open loop, whereas insulin dosing was performed by a control algorithm during closed loop.
resultsIn silico design resulted in rapid (less than 6 months compared to years of animal trials) and cost-effective system development, testing, and regulatory approvals in the United States, Italy, and France. In the clinic, compared to open-loop, closed-loop control reduced nocturnal hypoglycemia (blood glucose below 3.9 mmol/liter) from 23 to 5 episodes (p<.01) and increased the amount of time spent overnight within the target range (3.9 to 7.8 mmol/liter) from 64% to 78% (p=.03).
conclusionsIn silico experiments can be used as viable alternatives to animal trials for the preclinical testing of insulin treatment strategies. Compared to open-loop treatment under identical conditions, closed-loop control improves the overnight regulation of diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.