ArticleJournal of viral hepatitis2012
Integrated internist - addiction medicine - hepatology model for hepatitis C management for individuals on methadone maintenance.
Article in Journal of viral hepatitis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Evidence-based interventions to enhance assessment, treatment, and adherence in the chronic Hepatitis C care continuum.The International journal on drug policy · 2015Pooled it
- Recommendations for the management of hepatitis C virus infection among people who inject drugs.The International journal on drug policy · 2015Guideline
- Determinants of hepatitis C virus treatment completion and efficacy in drug users assessed by meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Pooled it
- Trial
- Viral hepatitis among drug users in methadone maintenance: associated factors, vaccination outcomes, and interventions.Journal of addictive diseases · 2014Trial
- A randomized trial of a hepatitis care coordination model in methadone maintenance treatment.American journal of public health · 2013Trial
- Developing a modified directly observed therapy intervention for hepatitis C treatment in a methadone maintenance program: implications for program replication.The American journal of drug and alcohol abuse · 2012Trial
- Article
- Engaging people who use drugs in clinical research: integrating facilitated telemedicine for HCV into substance use treatment.Research involvement and engagement · 2023Article
- Hepatitis C Virus Infection in Persons Who Inject Drugs in the Middle East and North Africa: Intervention Strategies.Viruses · 2021Review
- Substance Use Disorders in Recently Hospitalized Patients With Cirrhosis.Journal of addiction medicine · 2020Article
- Rationale and design of a randomized pragmatic trial of patient-centered models of hepatitis C treatment for people who inject drugs: The HERO study.Contemporary clinical trials · 2019Article
- Integrated care for methadone maintenance patients with hepatitis C virus infection.The Kaohsiung journal of medical sciences · 2019Article
- Evidence-based and guideline-concurrent responses to narratives deferring HCV treatment among people who inject drugs.Harm reduction journal · 2019Article
- Practical steps to improve chronic hepatitis C treatment in people with opioid use disorder.Hepatic medicine : evidence and research · 2019Article
- Treatment of Chronic Hepatitis C in Patients Receiving Opioid Agonist Therapy: A Review of Best Practice.Infectious disease clinics of North America · 2018Review
- Integrating Care for Patients With Chronic Liver Disease and Mental Health and Substance Use Disorders.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2018Article
- Observational
- Toward Optimal Control of Hepatitis C Virus Infection in Persons With Substance Use Disorders.Annals of internal medicine · 2017Article
- Medical and Behavioral Approaches to Engage People Who Inject Drugs Into Care for Hepatitis C Virus Infection.Addictive disorders & their treatment · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Despite a high prevalence of hepatitis C virus (HCV) among drug users, HCV evaluation and treatment acceptance are extremely low among these patients when referred from drug treatment facilities for HCV management. We sought to increase HCV treatment effectiveness among patients from a methadone maintenance treatment program (MMTP) by maintaining continuity of care. We developed, instituted and retrospectively assessed the effectiveness of an integrated, co-localized care model in which an internist-addiction medicine specialist from MMTP was embedded in the hepatitis clinic. Methadone maintenance treatment program patients were referred, evaluated by the internist and hepatologist in hepatitis clinic and provided HCV treatment with integration between both sites. Of 401 evaluated patients, anti-HCV antibody was detected in 257, 86% of whom were older than 40 years. Hepatitis C virus RNA levels were measured in 222 patients, 65 of whom were aviremic. Of 157 patients with detectable HCV RNA, 125 were eligible for referral to the hepatitis clinic, 76 (61%) of whom accepted and adhered with the referral. Men engaged in MMTP <36 months were significantly less likely to be seen in hepatitis clinic than men in MMTP more than 36 months (odds ratio = 7.7; 95% confidence interval 2.6-22.9) or women. We evaluated liver histology in 63 patients, and 83% had moderate to advanced liver disease. Twenty-four patients initiated treatment with 19 completing and 13 (54%) achieving sustained response. In conclusion, integrated care between the MMTP and the hepatitis clinic improves adherence with HCV evaluation and treatment compared to standard referral practices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.