ReviewBrain pathology (Zurich, Switzerland)2011
Molecular diagnostics in embryonal brain tumors.
Review in Brain pathology (Zurich, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism.Acta neuropathologica communications · 2019Article
- Is there an increased risk of spinal relapse in standard-risk medulloblastoma/primitive neuroectodermal tumor patients who receive only a reduced dose of craniospinal radiotherapy?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Effect of small nuclear ribonucleoprotein-associated polypeptide N on the proliferation of medulloblastoma cells.Molecular medicine reports · 2015Article
- Wnt activation affects proliferation, invasiveness and radiosensitivity in medulloblastoma.Journal of neuro-oncology · 2015Article
- Long noncoding RNA profiles reveal three molecular subtypes in glioma.CNS neuroscience & therapeutics · 2014Article
- The role of CD133+ cells in a recurrent embryonal tumor with abundant neuropil and true rosettes (ETANTR).Brain pathology (Zurich, Switzerland) · 2014Article
- A developmental program drives aggressive embryonal brain tumors.Nature genetics · 2014Article
- MyoD is a tumor suppressor gene in medulloblastoma.Cancer research · 2013Article
- OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells.Cancer research · 2012Article
- Analysis of chromosome 19q13.42 amplification in embryonal brain tumors with ependymoblastic multilayered rosettes.Brain pathology (Zurich, Switzerland) · 2012Article
- Infratentorial medulloepithelioma with divergent differentiation: Possibly a predictor of poor outcome.Journal of pediatric neurosciences · 2012Article
- Subgroup-specific alternative splicing in medulloblastoma.Acta neuropathologica · 2012Article
- Matching mice to malignancy: molecular subgroups and models of medulloblastoma.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Brain pathology (Zurich, Switzerland) · 2011Review
- Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct.Acta neuropathologica · 2011Article
- Clinical, pathological, and molecular data on desmoplastic/nodular medulloblastoma: case studies and a review of the literature.Clinical neuropathologyArticle
- Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.In vivo (Athens, Greece)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Embryonal brain tumors are a heterogeneous group of neoplasms united by the presence of poorly differentiated stem-like cells. Molecular details are increasingly being used to separate them into biologically and clinically meaningful groups. For medulloblastoma, integrated mRNA expression profiling and DNA analysis by a number of research groups defines 4-6 distinctive molecular variants. A subset with prominent Wnt activity is associated with good clinical outcomes and classic histology. Medulloblastomas showing a Hedgehog gene expression signature are frequently of the desmoplastic/nodular subtype. Interestingly, Hedgehog activity is found in tumors arising either in infants or older teenagers and adults. The association of clinically aggressive medulloblastoma with MYC expression, large cell/anaplastic change and high levels of photoreceptor differentiation transcripts has also been noted in several studies. Immunohistochemical analysis of just one or two genes per molecular medulloblastoma variant may be sufficient for accurate classification, and this would be of great practical utility if validated. Advances have also been made in the classification of central nervous system (CNS) Primitive Neuroectodermal Tumors (PNET), as several groups have identified an amplicon at chromosome 19q13.41-42, which appears to define a unique PNET subtype associated with prominent true rosettes, young age and very poor outcomes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.